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Autor:
Rhys S. Allan, Naiara G. Bediaga, Gaetano Naselli, Timothy M. Johanson, Leonard C. Harrison, Nadia Iannarella, Christine R. Keenan
Publikováno v:
Blood. 135:2049-2058
Loss of heterochromatin has been proposed as a universal mechanism of aging across different species and cell types. However, a comprehensive analysis of hematopoietic changes caused by heterochromatin loss is lacking. Moreover, there is conflict in
Autor:
Marina Cella, Mary C. Dinauer, Elaine Kulm, Michelle A. Ritter, Jahnavi Aluri, Alicia Bach, Elise M. Rizzi, Christina Bemrich-Stolz, Maleewan Kitcharoensakkul, Magdalena Walkiewicz, Jack J. Bleesing, Yi Shan Lee, James A. Connelly, Amy M. Scurlock, Laura G. Schuettpelz, Marwan Shinawi, Shirley M. Abraham, Saara Kaviany, V. Koneti Rao, Jonathan D. Powell, Jeffrey J. Bednarski, Peggy L. Kendall, Luana Chiquetto Paracatu, Raphaela Goldbach-Mansky, Christopher D. Putnam, Michael T. Harmon, Adriana Almeida de Jesus, Scott W. Canna, Stacie M. Jones, Morgan Similuk, Matthew M. Demczko, Nermina Saucier, Suk See De Ravin, Michael Joyce, Molly P. Keppel, Megan A. Cooper
Publikováno v:
Blood
Inborn errors of immunity (IEI) are a genetically heterogeneous group of disorders with a broad clinical spectrum. Identification of molecular and functional bases of these disorders is important for diagnosis, treatment, and an understanding of the
Autor:
Kimberly Boelte, Megan Karwan, Tim Chan, Howard A. Young, Deborah L. Hodge, Fan-ching Lin, Bahara Saleh, Jonathan R. Keller
Publikováno v:
Blood. 124:3699-3708
Aplastic anemia (AA) is characterized by hypocellular marrow and peripheral pancytopenia. Because interferon gamma (IFN-γ) can be detected in peripheral blood mononuclear cells of AA patients, it has been hypothesized that autoreactive T lymphocytes
Autor:
Terence H. Rabbitts, Jacob T. Jackson, Matthew P. McCormack, Nicholas J. Slater, Wei Shi, David J. Curtis, Cedric S. Tremblay, Chayanica Nasa, Benjamin J. Shields
Publikováno v:
Blood. 122:2093-2103
Lmo2 is an oncogenic transcription factor that is frequently overexpressed in T-cell acute lymphoblastic leukemia (T-ALL), including early T-cell precursor ALL (ETP-ALL) cases with poor prognosis. Lmo2 must be recruited to DNA by binding to the hemat
Autor:
Chunmei Zhang, Runtao Gao, Lingyun Sun, Huayong Zhang, Ousheng Liu, Zhipeng Fan, Yaozhong Ding, Junji Xu, Gang Ding, Wanjun Chen, Jonathan S. Bromberg, Songlin Wang, Dayong Liu, Dandan Wang
Publikováno v:
Blood. 120:3142-3151
Sjogren syndrome (SS) is a systemic autoimmune disease characterized by dry mouth and eyes, and the cellular and molecular mechanisms for its pathogenesis are complex. Here we reveal, for the first time, that bone marrow mesenchymal stem cells in SS-
Autor:
Markus Hansson, Mats Brune, Anna Martner, Kristoffer Hellstrand, Fredrik B. Thorén, Ali A. Akhiani, Johan Aurelius, Lars Palmqvist
Publikováno v:
Blood. 119:5832-5837
Dysfunction of T cells and natural killer (NK) cells has been proposed to determine the course of disease in acute myeloid leukemia (AML), but only limited information is available on the mechanisms of lymphocyte inhibition. We aimed to evaluate to w
Autor:
Priya Koppikar, Ross L. Levine, Erin T. St Angelo, Brian C. Betts, Shane A. Curran, Glenn Heller, Omar Abdel-Wahab, James W. Young
Publikováno v:
Blood. 118:5330-5339
Janus kinase-2 (JAK2) conveys receptor-binding signals by several inflammatory cytokines, including IL-6, via phosphorylation of signal transducer and activator of transcription 3 (STAT3). We demonstrate that selective JAK2 inhibition by TG101348 dur
Autor:
Alberto Orfao, Winfried F. Pickl, Ricardo Morilla, John Swansbury, Marie C. Béné, Herbert Strobl, Sue Ashley, Estella Matutes, Georg Hopfinger, Petr Lemez, Mars B. van 't Veer, Richard Schabath, Andishe Attarbaschi, Wolf-Dieter Ludwig, Anna Porwit
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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The features of 100 mixed-phenotype acute leukemias (MPALs), fulfilling WHO 2008 criteria, are documented. Myeloid and T-lineage features were demonstrated by cytoplasmic myeloperoxidase and CD3; B-lineage features were demonstrated by at least 2 B-l
Publikováno v:
Blood. 117:108-117
T-cell development is critically dependent on the activities of the Src-family kinases p56lck and p59fyn. While Lck plays a dominant role in the initiation of T-cell receptor (TCR) signaling and in thymocyte differentiation, Fyn plays a more subtle r
Autor:
Bartlomiej Przychodzen, Nicholas Lea, Alexander E. Smith, Jaroslaw P. Maciejewski, Norbert Gattermann, Ulrich Germing, Joop Gaken, Erick E. Nasser, ZiYi Lim, Syed A Mian, Austin G. Kulasekararaj, Azim M Mohamedali, Claire Shooter, Nigel Westwood, Corinna Strupp, Ghulam J. Mufti
Publikováno v:
Blood. 116:3923-3932
Mutations in the TET2 gene are frequent in myeloid disease, although their biologic and prognostic significance remains unclear. We analyzed 355 patients with myelodysplastic syndromes using “next-generation” sequencing for TET2 aberrations, 91 o