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Autor:
Andrew D. Campbell, James Douglas Engel, Shuaiying Cui, Osamu Tanabe, Michael Sierant, Kim Chew Lim, Lihong Shi
Publikováno v:
Blood. 125:1477-1487
The orphan nuclear receptors TR2 and TR4 have been shown to play key roles in repressing the embryonic and fetal globin genes in erythroid cells. However, combined germline inactivation of Tr2 and Tr4 leads to periimplantation lethal demise in inbred
Autor:
Gabrielle Rabu, Brian J. Druker, Jefferson Terry, Nagarajan Kannan, Jerald P. Radich, Philip A. Beer, Ivan Sloma, Sonja Babovic, Elizabeth Bulaeva, Wendy N. Erber, Keith R. Loeb, Marc M. Loriaux, David J.H.F. Knapp, Paul H. Miller, Connie J. Eaves, Kathy Heel
Publikováno v:
Blood. 125:504-515
Without effective therapy, chronic-phase chronic myeloid leukemia (CP-CML) evolves into an acute leukemia (blast crisis [BC]) that displays either myeloid or B-lymphoid characteristics. This transition is often preceded by a clinically recognized, bu
Autor:
Bernard G. Forget, Hui Yu, Geoffrey Neale, Sheng Zhou, Han M. Lee, Zhijun Ma, Hui Zhang, Brian P. Sorrentino
Publikováno v:
Blood. 124:1737-1747
Overexpression of HOXB4 in hematopoietic stem cells (HSCs) leads to increased self-renewal without causing hematopoietic malignancies in transplanted mice. The molecular basis of HOXB4-mediated benign HSC expansion in vivo is not well understood. To
Autor:
Wei Liu, Xin Duan, James C. Mulloy, H. Leighton Grimes, Cindy L. Hochstetler, Benjamin Mizukawa, Yi Zheng, Eric O'Brien, Emily Orr, Daniel C. Moreira, Mark Wunderlich
Publikováno v:
Blood. 130(11)
As a central regulator of cell polarity, the activity of CDC42 GTPase is tightly controlled in maintaining normal hematopoietic stem and progenitor cell (HSC/P) functions. We found that transformation of HSC/P to acute myeloid leukemia (AML) is assoc
Autor:
Sonia T. Chelbi, Rémy Tallant, Bojan Bujisic, Léa Zaffalon, Francesco Bertoni, Fabio Martinon, Aude De Gassart, Michel Gilliet, Olivier Demaria
Publikováno v:
Blood, vol. 129, no. 17, pp. 2420-2428
The endoplasmic reticulum kinase inositol-requiring enzyme 1 (IRE1) and its downstream target X-box-binding protein 1 (XBP1) drive B-cell differentiation toward plasma cells and have been shown to contribute to multiple myeloma development; yet, litt
Autor:
Heiko Stahl, Susanne A. Hahn, Franz-Joseph Schneider, Christian Becker, Helmut Jonuleit, Andrea Tuettenberg, Anita Correll
Publikováno v:
Blood. 122:1182-1191
Glycoprotein A repetitions predominant (GARP) is expressed on the surface of activated human regulatory T cells (Treg) and regulates the bioavailability of transforming growth factor-β (TGF-β). GARP has been assumed to require membrane anchoring. T
Autor:
Kara A. Scheibner, Jae-Woong Lee, Kimberly Cramer-Morales, Margaret Nieborowska-Skorska, Mariusz A. Wasik, Mhairi Copland, Tomasz Skorski, Michelle Padget, Curt I. Civin, David Irvine, Huimin Geng, Kimberly Haas, Markus Müschen, Feyruz V. Rassool, Wayne E. Childers, Tomasz Sliwinski, Darshan Roy, Artur Slupianek
Publikováno v:
Blood. 122:1293-1304
Homologous recombination repair (HRR) protects cells from the lethal effect of spontaneous and therapy-induced DNA double-stand breaks. HRR usually depends on BRCA1/2-RAD51, and RAD52-RAD51 serves as back-up. To target HRR in tumor cells, a phenomeno
Autor:
Naoyuki Katayama, Kei Suzuki, Masahiro Masuya, Satomi Ishii, Tetsuya Nosaka, Hideaki Nakajima, Akihide Nakamura, Fumi Shibata-Minoshima, Yutaka Enomoto, Ryoichi Ono, Toshio Kitamura, Eri Miyata
Publikováno v:
Blood. 122:1271-1283
Oncogenic transformation requires unlimited self-renewal. Currently, it remains unclear whether a normal capacity for self-renewal is required for acquiring an aberrant self-renewal capacity. Our results in a new conditional transgenic mouse showed t
Autor:
Sophie Louwette, Rik Gijsbers, Thomas Tousseyn, Alexandre Kauskot, Peter Verhamme, Christophe Vandenbriele, Marc Hoylaerts, Kathleen Freson
Publikováno v:
Blood. 121:5208-5217
Platelet Endothelial Aggregation Receptor-1 (PEAR1) participates in platelet aggregation via sustaining αIIbβ3 activation. To investigate the role of PEAR1 in platelet formation, we monitored and manipulated PEAR1 expression in vitro in differentia
Autor:
Xiaodong Cheng, Xiangfei Liu, Mary K. Reinhard, W. Stratford May, Richard L. Bennett, Michael Byrne
Publikováno v:
Blood. 121:3364-3374
Protein kinase R (PKR) is an interferon (IFN)-inducible, double-stranded RNA-activated kinase that initiates apoptosis in response to cellular stress. To determine the role of PKR in hematopoiesis, we developed transgenic mouse models that express ei