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Autor:
Rhys S. Allan, Naiara G. Bediaga, Gaetano Naselli, Timothy M. Johanson, Leonard C. Harrison, Nadia Iannarella, Christine R. Keenan
Publikováno v:
Blood. 135:2049-2058
Loss of heterochromatin has been proposed as a universal mechanism of aging across different species and cell types. However, a comprehensive analysis of hematopoietic changes caused by heterochromatin loss is lacking. Moreover, there is conflict in
Autor:
Georg W. Herget, Bodo Grimbacher, Marta Rizzi, Arianna Troilo, Klaus Warnatz, Justyna Rawluk, Jens Thiel, Claudia Wehr, Michele Proietti, Natalie Frede, Miriam Erlacher, Raquel Lorenzetti, Nadezhda Camacho-Ordonez, Reinhard E. Voll, Julian Staniek, M.-T. Schleyer, Nils Venhoff, Lukas Konstantinidis, Ulrich Salzer, Iga Janowska
Publikováno v:
Blood
Common variable immunodeficiency (CVID) is a disease characterized by increased susceptibility to infections, hypogammaglobulinemia, and immune dysregulation. Although CVID is thought to be a disorder of the peripheral B-cell compartment, in 25% of p
Autor:
Margaret A. Goodell, Grant A. Challen
Publikováno v:
Blood
The discovery of clonal hematopoiesis (CH) in older individuals has changed the way hematologists and stem cell biologists view aging. Somatic mutations accumulate in stem cells over time. While most mutations have no impact, some result in subtle fu
Publikováno v:
Blood. 132:123-131
The hemostatic system plays pivotal roles in injury repair, innate immunity, and adaptation to inflammatory challenges. We review the evidence that these vascular-protective mechanisms have nontraditional roles in hematopoietic stem cell (HSC) mainte
Autor:
Alena Musilova, Jan Stary, Ester Mejstrikova, Jan Zuna, Jan Stuchly, Julia Starkova, Ondrej Hrusak, Michaela Kotrova, Marketa Zaliova, Karel Fiser, Jan Trka
Publikováno v:
Blood. 128:2263-2266
To the editor: Mixed phenotype acute leukemias (MPALs) are a rare subset of acute leukemias that cannot be unambiguously assigned to a single hematopoietic lineage because of the significant expression of antigens from additional lineages. This subse
Autor:
Hans Reimer Rodewald, Thomas Höfer
Publikováno v:
Blood
Advances in genetic labeling and barcoding of hematopoietic stem cells (HSCs) in situ now allow direct measurements of physiological HSC output, both quantitatively and qualitatively. Turning on a heritable label in HSCs and measuring the kinetics of
Publikováno v:
Blood. 125:1452-1459
Interferon regulatory factor 8 (IRF8) is a key regulator of myelopoiesis in mice and humans. IRF8-deficient mice exhibit increased neutrophil numbers but defective monocyte and dendritic cell (DC) production. It has therefore been hypothesized that I
Autor:
Karl Welte, Johann Meyer, Julia Skokowa, Inna Kuznetsova, Cornelia Zeidler, Maksim Klimiankou, Kshama Gupta, Malcolm A.S. Moore, Olga Klimenkova
Publikováno v:
Blood. 123:2550-2561
The transcription factor lymphoid enhancer-binding factor 1 (LEF-1), which plays a definitive role in granulocyte colony-stimulating factor (G-CSF) receptor-triggered granulopoiesis, is downregulated in granulocytic progenitors of severe congenital n
Autor:
Adam C. Gower, Aline M. Galvão, Jason A. Mills, Jyh-Chang Jean, Yu Yao, Lisa M. Sullivan, Spencer K. Sullivan, Paul Gadue, Lin Lu, Gustavo Mostoslavsky, Helen Mac, Mitchell J. Weiss, Prasuna Paluru, Lei Ying, Darrell N. Kotton, Amel Omari, A. Spira, Dongbin Xu, Deborah L. French, Kai Wang, Steven S. Shen
Publikováno v:
Blood. 122:2047-2051
Induced pluripotent stem cells (iPSCs) hold great promise for modeling human hematopoietic diseases. However, intrinsic variability in the capacities of different iPSC lines for hematopoietic development complicates comparative studies and is current
Autor:
Marcos J. Araúzo-Bravo, Verónica Ayllón, Oscar Navarro-Montero, Pedro J. Real, Verónica Ramos-Mejía, Clara Bueno, Pablo Menendez, Damia Romero-Moya, Rosa Montes
Publikováno v:
Blood. 121:3867-3878
Mixed-lineage leukemia (MLL)-AF4 fusion arises prenatally in high-risk infant acute pro-B-lymphoblastic leukemia (pro-B-ALL). In human embryonic stem cells (hESCs), MLL-AF4 skewed hematoendothelial specification but was insufficient for transformatio