Zobrazeno 1 - 10
of 16
pro vyhledávání: '"P Cooke"'
Autor:
Ryan Knihtila, Michael P. Cooke, Tahirih L. Lamothe, Leanne Lanieri, Sean McDonough, Anthony E. Boitano, Prashant raj Bhattarai, John C. Davis, Rahul Palchaudhuri, Junia Dushime, Jennifer L. Proctor, Oliver Miske, Nidhi Jain, Ganapathy N. Sarma, Bradley R. Pearse, Kellie Latimer
Publikováno v:
Blood. 136:47-48
Hematopoietic stem cell transplant (HSCT) can be a highly effective, and often curative, treatment for patients with AML. At present, myeloablative conditioning (MAC) regimens are associated with severe acute and long-term toxicities. A subset of tra
Autor:
Geoff O Gillard, Jennifer L Proctor, Sharon L. Hyzy, Catherine Rhee, Elizabeth W. Scadden, Matthias Nahrendorf, David T. Scadden, Karin Gustafsson, Vanessa Frodermann, Michael P. Cooke, Anthony E. Boitano, Rahul Palchaudhuri
Publikováno v:
Blood. 136:34-35
Cardiovascular disease (CVD) is the leading cause of death worldwide. Recently, age-related clonal hematopoiesis (CH) has been recognized as a risk factor for CVD of comparable magnitude to smoking, hypertension and hypercholesteremia. While these ot
Autor:
Nicholas M. Clark, Hans-Peter Kiem, Anthony E. Boitano, Jennifer L. Proctor, Katelyn J. Hammond, Charlotte Mcdonagh, Anjali Bhat, Geoff O Gillard, Rahul Palchaudhuri, Tahirih L. Lamothe, Ganapathy N. Sarma, Sharon L. Hyzy, Bradley R. Pearse, Bruce R. Blazar, John C. Davis, John E. Wagner, Michael P. Cooke, Asim Saha
Publikováno v:
Blood. 136:31-31
Introduction Allogeneic hematopoietic stem cell transplant (Allo-HSCT) is a potentially curative treatment for malignant and non-malignant blood disorders. However, current conditioning regimens limit the use of this curative procedure in many eligib
Autor:
Nathaniel S. Linde, Kellie Latimer, Lena Kien, John F. Tisdale, Aylin C. Bonifacino, Qing Li, Rajiv Panwar, Naoya Uchida, Robert E. Donahue, Anthony E. Boitano, Melissa L. Brooks, Sharon L. Hyzy, Rahul Palchaudhuri, Michael P. Cooke, Sean McDonough, Ganapathy N. Sarma, Bradley R. Pearse, Junia Dushime, Charlotte Mcdonagh, Allen E. Krouse, Pranoti Sawant, Jennifer L. Proctor
Publikováno v:
Blood. 134:610-610
Autologous hematopoietic stem cell transplantation (Auto-HSCT) with gene-modification techniques represents a potential cure for multiple genetic blood diseases. Despite its broad curative potential, auto-gene modified HSCT is currently limited due t
Autor:
Kevin A. Goncalves, Melissa L. Brooks, Michael P. Cooke, Sharon L. Hyzy, Hans J. Hertzler, Anthony E. Boitano
Publikováno v:
Blood. 134:4424-4424
Background . Allogeneic hematopoietic stem cell transplant (HSCT) is a promising approach to halt disease progression and prevent or ameliorate neurological symptoms arising from select inherited metabolic disorders (IMDs). Donor-derived cells, inclu
Autor:
Anjali Bhat, Michael P. Cooke, Oliver Mikse, Prashant raj Bhattarai, Charlotte F. Mcdonough, Geoff O Gillard, Tahirih L. Lamothe, Sharon L. Hyzy, Rahul Palchaudhuri, Ganapathy N. Sarma, Bradley R. Pearse, Jennifer L. Proctor, Anthony E. Boitano, Sean McDonough, Melissa L. Brooks, Pranoti Sawant
Publikováno v:
Blood. 134:3208-3208
Resetting the immune system through autologous hematopoietic stem cell transplant (autoHSCT) is a highly effective treatment in selected patients with autoimmune diseases. AutoHSCT can induce long-term remission (up to 15 years) with 70-80% progressi
Autor:
David H. McKenna, Darin Sumstad, Claudio G. Brunstein, Bruce R. Blazar, John E. Wagner, Jeffrey S. Miller, Glen D. Raffel, Heather E. Stefanski, Anthony E. Boitano, Todd E. DeFor, John C. Davis, Michael P. Cooke
Publikováno v:
Blood. 134:804-804
Background. HSC dose and HLA match are independent risk factors that impact non-relapse mortality in children and adults undergoing umbilical cord blood (UCB) transplant for acute leukemia (Eapen et al. Blood 2014 123:133-140). Low number of CD34+ HS
Autor:
Lukasz Biernat, Dwight M. Morrow, Veit Schmelmer, Patrick C. Falahee, Jason Neale, Kevin A. Goncalves, Glen D. Raffel, Michael P. Cooke, John F. DiPersio, John C. Davis, Steven M. Devine, Jonathan Hoggatt, Haley Howell, Anthony E. Boitano
Publikováno v:
Blood. 134:1961-1961
Background Granulocyte colony-stimulating factor (G-CSF) is the standard of care for mobilization of hematopoietic stem cells (HSCs). G-CSF requires 4-7 days of injections and often multiple aphereses to acquire sufficient CD34+ cells for transplant.
Autor:
Rahul Palchaudhuri, Ganapathy N. Sarma, Bradley R. Pearse, Jennifer L. Proctor, Qing Li, Lena Kien, Junia Dushime, Nathan M Kallen, Pranoti Sawant, Michael P. Cooke, Anthony E. Boitano, Sharon L. Hyzy, Rajiv Panwar, Sean McDonough, Melissa L. Brooks, Molly A McShea, Charlotte Mcdonagh, Hillary L. Adams
Publikováno v:
Blood. 132:3314-3314
Background: Genotoxic conditioning prior to allogeneic and autologous bone marrow transplantation (BMT) limits the use of these potentially curative treatments due to risks of regimen-related morbidities and mortality, including risks of organ toxici
Autor:
Shuping Li, Dwight M. Morrow, Kevin A. Goncalves, Anthony E. Boitano, Sharon L. Hyzy, Patrick C. Falahee, Michael P. Cooke
Publikováno v:
Blood. 132:116-116
Background. The majority of bone marrow transplants (BMTs) are performed with granulocyte-colony stimulating factor (G-CSF) mobilized peripheral blood (mPB) as the source of hematopoietic stem cells (HSCs) for patients. Up to 80% of mPB allogeneic re