Zobrazeno 1 - 10
of 12
pro vyhledávání: '"329"'
Publikováno v:
Blood. 110:1310-1310
Syk kinase is central to FcR and B-cell signaling in inflammatory cells. By inhibiting syk, and thereby IgG signaling, R788 (a small molecule prodrug for biologically active R406), inhibits the downstream activation of mast cells, macrophages and B-c
Autor:
R. Andrew Harkins, Sharvil P. Patel, Michelle J. Lee, Christopher R. Flowers, Jeffrey M. Switchenko
Publikováno v:
Blood. 134:3416-3416
PURPOSE: Diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous disease. Patients exhibit a 30%-40% relapse/refractory rate on standard first-line therapy and are known to have poor outcomes with relapsed/refractory disease, indicating a
Publikováno v:
Blood. 132:4979-4979
Background Although significant advances have been made over the past 10 years in the treatment of Immune Thrombocytopenia (ITP), challenges remain in addressing the burden of disease and unmet needs of patients. In rare diseases especially, natural
Autor:
Suzanne R. Hayman, Morie A. Gertz, Steven R. Zeldenrust, Francis K. Buadi, Miriam Hobbs, Moritz Binder, Shaji Kumar, Martha Q. Lacy, Angela Dispenzieri, Wilson I. Gonsalves, Ronald S. Go, Prashant Kapoor, John A. Lust, Robert A. Kyle, Taxiarchis Kourelis, S. Vincent Rajkumar, Rahma Warsame, Amie Fonder, Stephen J. Russell, Nelson Leung, Arjun Lakshman, Lisa Hwa
Publikováno v:
Blood. 132:4497-4497
Background: The introduction of novel therapeutics has led to improved outcomes in patients with multiple myeloma (MM). MM and its precursor lesion smoldering multiple myeloma (SMM) have traditionally been associated with increased mortality despite
Autor:
Binal N. Shah, Rasha Raslan, Jin Han, Michel Gowhari, Andrew Srisuwananukorn, Xu Zhang, Robert E. Molokie, Santosh L. Saraf, Victor R. Gordeuk
Publikováno v:
Blood Adv
Sickle cell disease (SCD) is an inherited red blood cell disorder that leads to vaso-occlusion, endothelial damage, and activation of pro-coagulant pathways. Recent studies have demonstrated that thrombotic episodes occur at a 3- to 100-fold higher r
Autor:
Genovefa A. Papanicolaou, Yao-Ting Hayden Huang, Victoria Gonzalez, Anna Kaltsas, Marina Kerpelev, Yeon Joo Lee, Seong Jin Kim
Publikováno v:
Blood. 126:3303-3303
Background: Streptococcus pneumoniae is a major cause of sepsis, pneumonia and meningitis leading to significant morbidity and mortality. Invasive pneumococcal disease (IPD) and mortality rates in cancer patients (pts) are higher than in the general
Publikováno v:
Blood. 126:4714-4714
Background Studies of hospital discharge data and large observational cohorts show that the incidence of venous thromboembolism (VTE) varies by race. We sought to determine the incidence of VTE in each of the following ethnic groups Caucasians, Afric
Autor:
Jennifer S. Temel, Tanya Keenan, Yi-Bin Chen, Harry VanDusen, Areej El-Jawahri, Daniel J. DeAngelo, Amir T. Fathi, Thomas W. LeBlanc, Philip C. Amrein, David P. Steensma, Lara Traeger, Richard Stone, Karen K. Ballen, Martha Wadleigh, Gregory A. Abel, Gabriela S. Hobbs
Publikováno v:
Blood. 126:2104-2104
Introduction: Older adults (≥ 60 years) with acute myeloid leukemia (AML) generally have a poor prognosis and a high rate of health care utilization including intensive care unit (ICU) admissions. While the outcomes of older patients with advanced
Publikováno v:
Blood. 124:4856-4856
Background: Health services and outcomes research in sickle cell disease (SCD) has been limited by inadequate population-based surveillance and reliance on ICD-9 codes to identify individuals with SCD. The accuracy of ICD-9 coding in administrative c
Autor:
Markus Loeffler, Norbert Schmitz, Randy D. Gascoyne, Roopesh Kansara, Michael Pfreundschuh, Bertram Glass, Samira Zeynalova, Kerry J. Savage, David Scott, Diego Villa, Laurie H. Sehn, Joseph M. Connors, Maike Nickelsen, Marita Ziepert
Publikováno v:
Blood. 124:394-394
[Graphic][1] Introduction : Despite the improvement of outcome of aggressive B-cell lymphomas in the rituximab treatment era, central nervous system (CNS) relapse continues to pose a significant management problem. It remains a challenge to select pa