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Autor:
Lauren Schaff, Christian Grommes
Publikováno v:
Blood. 140:971-979
Primary central nervous system lymphoma (PCNSL) is a rare extranodal lymphomatous malignancy that affects the brain, spinal cord, leptomeninges, or vitreoretinal space, without evidence of systemic involvement. The diagnosis of PCNSL requires a high
Publikováno v:
Blood. 139:1973-1986
Disseminated intravascular coagulation (DIC) is a syndrome triggered by infectious and noninfectious pathologies characterized by excessive generation of thrombin within the vasculature and widespread proteolytic conversion of fibrinogen. Despite div
Autor:
Hiroshi Imanaga, Tatsuya Terasaki, Koichi Akashi, Kensuke Sasaki, Fumihiko Nakao, Takeshi Inukai, Jumpei Nogami, Takahiro Maeda, Els Verhoeyen, Takuji Yamauchi, Koshi Akahane, Yuichiro Semba
Publikováno v:
Blood
Acute lymphoblastic leukemia (ALL) harboring the IgH-CRLF2 rearrangement (IgH-CRLF2-r) exhibits poor clinical outcomes and is the most common subtype of Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL). While multiple chemother
Autor:
Dan Guo, Wenqi Zhu, Qian Ren, Tao Cheng, Peiwen Zhang, Nan Wang, Jing Yin, Yangyang Zhao, Na You, Xiao-Tong Ma
Publikováno v:
Blood. 138:464-479
Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy for which there is an unmet need for novel treatment strategies. Here, we characterize the growth arrest and DNA damage-inducible gene gamma (GADD45g) as a novel tumor suppressor
Autor:
Katherine A. Hajjar, Mary M. Ruisi, Maria T. DeSancho, Neha Kumar, Huigen Chen, Hannah Fassel
Publikováno v:
Blood. 137:2221-2230
Reduced plasma fibrinolysis has been identified as a potential risk factor for venous thromboembolism (VTE), but the role of cell surface fibrinolysis in VTE is unknown. The annexin A2/S100A10 complex serves as a coreceptor for plasminogen and tissue
Autor:
Panpan Han, Jun Peng, Guosheng Li, Yu Hou, Yang Liu, Haoyi Wang, Yunqi Sun, Tianshu Yu, Hai Zhou, Ming Hou, Xinguang Liu, Lizhen Li, Yajing Zhao, Pengcheng Xu, Xiang Hu, Tao Sun
Publikováno v:
Blood. 138:674-688
Our previous clinical study showed that low-dose decitabine exhibited sustained responses in nearly half of patients with refractory immune thrombocytopenia (ITP). The long-term efficacy of decitabine in ITP is not likely due to its simple role in in
Autor:
Brigitte Senechal, Mark B. Geyer, Marco L. Davila, Kevin J. Curran, Mithat Gonen, Mikhail Roshal, Isabelle Riviere, Michel Sadelain, Peter Maslak, Jessica Flynn, Kitsada Wudhikarn, Claudia Diamonte, Renier J. Brentjens, Jae H. Park, Xiuyan Wang, Elizabeth Halton
Publikováno v:
Blood
CD19-targeted chimeric antigen receptor (CAR) T-cell therapy has become a breakthrough treatment of patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). However, despite the high initial response rate, the majority of adult
Autor:
Dagmar Meyer zu Heringdorf, Corina Ratiu, Amro Elgheznawy, Voahanginirina Randriamboavonjy, Anastasia Kyselova, Ingrid Fleming, Mauro Siragusa, Alexander W. Mann, Beate Fisslthaler, Fredy Delgado Lagos
Publikováno v:
Blood. 137:1641-1651
Secreted modular calcium-binding protein 1 (SMOC1) is an osteonectin/SPARC-related matricellular protein, whose expression is regulated by microRNA-223 (miR-223). Given that platelets are rich in miR-223, this study investigated the expression of SMO
Autor:
Michael F. Moran, Biyin Cao, Xinliang Mao, Jinhao Chen, Jiefei Tong, Zubin Zhang, Xiaowen Tang, Depei Wu, A. Keith Stewart, Yujia Xu, Min Xu, Xue-han Chen
Publikováno v:
Blood. 137:1478-1490
The oncogenic transcription factor c-Maf has been proposed as an ideal therapeutic target for multiple myeloma (MM), but how to achieve it is still elusive. In the present study, we found the Otub1/c-Maf axis could be a potential target. Otub1, an OT
Autor:
Michael O. Breckwoldt, Manuel Feinauer, Wolfgang Wick, Varun Venkataramani, Katharina Gunkel, Maik Brune, Frank Winkler, Frank Thomas Mayer, Stefan W. Schneider, Anna S. Berghoff, Alexander Bauer, Bogdana Kovalchuk, Julia Grosch, Gergely Solecki, Jose Ramon Robador, Yannik Schwab, Matthia A. Karreman, Manuel Fischer, Cedric Tehranian
Publikováno v:
Blood
Clinically relevant brain metastases (BMs) frequently form in cancer patients, with limited options for effective treatment. Circulating cancer cells must first permanently arrest in brain microvessels to colonize the brain, but the critical factors