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pro vyhledávání: '"785"'
Publikováno v:
Blood. 120:3789-3789
Abstract 3789 Introduction: Recently, genes affecting the splicing machinery have been found to be frequently mutated in MDS patients. The U2AF1 gene codes for one of these splicing components, showing two distinct mutational hot spots at amino acids
Autor:
C H Pui, J. L. Frestedt, David R. Head, J. H. Kersey, James R. Downing, Frederick G. Behm, Susana C. Raimondi
Publikováno v:
Blood. 86:1881-1886
Balanced translocations affecting the 11q23 region are among the most frequent chromosomal abnormalities in childhood acute lymphoblastic leukemia (ALL), comprising 5% to 6%. These cases consistently have a rearranged MLL gene and are associated with
Autor:
Ollivier Legrand, Anne Murati, Stefan N. Constantinescu, Pascale Saussoy, Marie-Christianne Vekemans, Jean Christophe Ianotto, Valérie Ugo, Isabelle Plo, William Vainchenker, Olivier Bluteau, M J Mozziconacci, Vincent Ribrag, Jean François Viallard, Christophe Marzac, Olivier Mansier, François Girodon, Nicole Casadevall, Eric Lippert, Florence Pasquier, Eric Solary, Alexandre Ji-Hye, Laurent Knoops, Xénia Cabagnols, Jean-Philippe Defour, Pascal Mossuz, Julie Mondet
Publikováno v:
Blood. 124:1823-1823
Recent advances in myeloproliferative neoplasms (MPN) have highlighted the prevalence of mutations in the calreticulin gene (CALR), bringing a major new actor in these disorders. CALR mutations were reported in 25% of ET and in 35% of MF patients, wh
Autor:
Xiangao Huang, Hearn Jay Cho, Scott Ely, Morton Coleman, Tricia Nardiello, Lloyd J. Old, Selina Chen-Kiang, Ruben Niesvizky, David Jayabalan, Achim A. Jungbluth, Maurizio DiLiberto, Anna Mei, Roger N. Pearse
Publikováno v:
Blood. 116:785-785
Abstract 785 The type I Melanoma Antigen GEne (MAGE) MAGE-A3 is commonly present in primary multiple myeloma cells and its expression is correlated with advanced disease and proliferation. MAGE-A3 belongs to the Cancer-Testis antigen (CTAg) family of
Publikováno v:
Blood. 50:1081-1092
Circulating erythropoietic precursors in normal men and patients with hemoglobinopathies were characterized in culture. Blood mononuclear cells harvested with a modification of the Ficoll-Isopaque technique were cultured in methylcellulose for 14 day
Publikováno v:
Blood. 31:699-709
1. Histidine decarboxylase was assayed in extracts from human leukocytes and the properties of the enzyme studied. 2. Leukocyte histidine decarboxylase was found to be substrate-specific, to require pyridoxal phosphate as co-enzyme, and to be inhibit