Zobrazeno 1 - 10
of 40
pro vyhledávání: '"72"'
Autor:
Kensuke Kojima, Jo Ishizawa, Michael Andreeff, Koichi Tazaki, Takahiko Seki, Dhruv Chachad, Kenji Nakamaru, R. Eric Davis, Keyur P. Patel, Sherry Pierce, Arvind Rao, Archie Tse, Courtney D. DiNardo
Publikováno v:
Blood. 128:2893-2893
Development of MDM2 inhibitors enabled successful induction of p53-mediated apoptosis in tumor cells without a risk of DNA damage. Early clinical trials of MDM2 inhibitors demonstrated proof-of-concept (Andreeff et al., Clin Can Res, 2015). However,
Publikováno v:
Blood. 118:5004-5004
Abstract 5004 Introduction: Amiloride is an FDA approved potassium-sparing diuretic which targets Na+/H+ exchanger isoform 1 (NHE1). NHE1 is responsible for the regulation of the intracellular pH, as well as cell-cycle and apoptosis. In supra-pharmac
Autor:
Karen J. Vigil, I. Raad, Richard E. Champlin, Mohsen Ghadimi Mahani, Ying Jiang, Roy F. Chemaly, Imrana Malik, Javier A. Adachi, Bruno Palma Granwehr, Susan Gaeta, Uday R. Popat
Publikováno v:
Blood. 116:1731-1731
Abstract 1731 Novel influenza A (2009/H1N1) is a new influenza virus of swine origin. The epidemiology, morbidity, and mortality are different from those of seasonal influenza viruses, with this new strain affecting younger patients. We describe the
Autor:
Aric Parnes, K. Gary J. Vanasse, Jee-Yeong Jeong, Masha Sverdlov, Nancy Berliner, Matthew Silver
Publikováno v:
Blood. 114:2507-2507
Abstract 2507 Poster Board II-484 Although the etiology of anemia remains unexplained in one third of elderly subjects, increasing evidence implicates chronic inflammation in the pathogenesis of anemia in the elderly population. We hypothesize that i
Autor:
Vanderson Rocha, Gérard Socié, Yulia Skvortsova, Raphaël Porcher, Carmen Bonfim, Marco A. Bittencourt, Eliane Gluckman, Marco Antonio Zago, Juliana F Fernandes, Marli Tavela, Ricardo Pasquini, Moema Santos
Publikováno v:
Blood. 110:1981-1981
Fanconi anaemia (FA) patients are known to have a markedly increased toxicity of chemotherapeutic agents, due to impairment in various important cellular processes, such as DNA repair. This toxicity had led to several alterations in preparative regim
Publikováno v:
Blood. 136:10-10
Background: Mantle cell lymphoma (MCL) is a distinctive B-cell non-Hodgkin's lymphoma characterized by poor prognosis. Despite clinical success of the covalent Bruton's tyrosine kinase (BTK) inhibitor ibrutinib, a subset of patients need to discontin
Publikováno v:
Blood. 69:1531-1534
Large multimers of von Willebrand factor (vWf) are released from the Weibel-Palade bodies (WPB) of cultured endothelial cells following treatment with a secretagogue, whereas predominantly dimeric forms are secreted constitutively. These two pools of
Autor:
Mónica Martín, Miguel Canales, Ihosvany Fernandez-Bello, Teresa Álvarez-Roman, Elena Monzón Manzano, Nora Butta, Raul Justo Sanz, María Isabel Rivas Pollmar, Víctor Jiménez-Yuste
Publikováno v:
Blood. 132:3738-3738
Background: The treatment goal for patients with immune thrombocytopenia (ITP) is to raise platelet counts to levels that minimize or stop bleeding. Thrombopoietin receptor agonists (TPO-RAs) have been successfully and extensively employed as second-
Autor:
Nadine Ajzenberg, Dominique Baruch, Paulette Legendre, Médina Mekrache, Christilla Bachelot-Loza, Abdel Saci
Publikováno v:
Blood. 101:4363-4371
Shear-induced platelet aggregation (SIPA) involves the sequential interaction of von Willebrand factor (VWF) with both glycoprotein Ib (GPIb) and αIIbβ3 receptors. Type 2B recombinant VWF (2B-rVWF), characterized by an increased affinity for GPIb,
Autor:
Soranobu Ninomiya, Nobuhiko Nakamura, Masahito Shimizu, Hisashi Tsurumi, Junichi Kitagawa, Takeshi Hara
Publikováno v:
Blood. 128:3693-3693
Introduction:Aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor well known to generate biological responses to dioxins. A recent study indicated that kynurenine was an endogenous ligand of AhR and was associated with suppressi