Zobrazeno 1 - 10
of 158
pro vyhledávání: '"11"'
Autor:
Craig C. Hofmeister, Lawrence H. Boise, Ryosuke Shirasaki, Jonathan L. Kaufman, Nisha Joseph, Benjamin G. Barwick, David L. Jaye, Jonathan J Keats, Constantine S. Mitsiades, Leonard T. Heffner, Benjamin Oberlton, Ajay K. Nooka, Vikas Gupta, Sagar Lonial, Shannon M. Matulis, Madhav V. Dhodapkar
Publikováno v:
Blood. 137:3604-3615
Venetoclax is a highly potent, selective BCL2 inhibitor capable of inducing apoptosis in cells dependent on BCL2 for survival. Most myeloma is MCL1-dependent; however, a subset of myeloma enriched for translocation t(11;14) is codependent on BCL2 and
Autor:
Li-Tzong Chen, Hui Chen Hsu, Ming-Shiang Wu, Chi Long Chen, Shin-Lian Doong, Sung-Hsin Kuo, Ann-Lii Cheng, Tsui Lien Mao, Jaw-Town Lin, Kun-Huei Yeh, Yi Shin Tzeng
Publikováno v:
Blood. 106:1037-1041
The t(11;18)(q21;q21) translocation is a specific marker for Helicobacter pylori-independent status of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, there are no reliable markers to predict tumor response to H pylori e
Autor:
Mark S. Cragg, Gordon K. Smyth, Marco J Herold, Andreas Strasser, Clare L. Scott, Lina Happo, Cassandra J. Vandenberg, Elisa S. Jansen, Jon M. Haga, Grant Dewson, Belinda Phipson, Suzanne Cory, Ewa M. Michalak
Publikováno v:
Blood. 116:5256-5267
DNA-damaging chemotherapy is the backbone of cancer treatment, although it is not clear how such treatments kill tumor cells. In nontransformed lymphoid cells, the combined loss of 2 proapoptotic p53 target genes, Puma and Noxa, induces as much resis
Autor:
Judith Dierlamm, Lorenzo Cerroni, Andreas Chott, Manfred Stolte, Markus Raderer, Andrea Lamprecht, Berthold Streubel, German Ott
Publikováno v:
Blood. 101(6)
T(11;18)(q21;q21) is the most common structural abnormality in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) leading to the fusion of the apoptosis inhibitor-2 (API2) gene and the MALT lymphoma-associat
Publikováno v:
Blood. 105:2519-2526
Glucocorticoids are among the most effective agents used in the treatment of childhood acute lymphoblastic leukemia (ALL), and patient response to treatment is an important determinant of long-term outcome. Despite its clinical significance, the mole
Autor:
Hans G. Drexler, Ralf Küppers, Monika Szczepanowski, Markus Löffler, Ilske Oschlies, Lorenz Trümper, Matthias Schlesner, Birgit Burkhardt, Alexander Claviez, Inga Vater, Jasmin Lisfeld, Markus Kreuz, Barbara Pienkowska-Grela, Michael Hummel, Carsten Schwaenen, Reiner Siebert, Maciej Rosolowski, Christian W. Kohler, Christine Damm-Welk, Christine Lefebvre, Inga Nagel, Wolfram Klapper, Robert B. Russell, Rabea Wagener, Roderick A. F. MacLeod, Swen Wessendorf, Itziar Salaverria, Elaine S. Jaffe, Patrick Adam, Grzegorz Rymkiewicz, Detlev Schindler, Rainer Spang, Idoia Martin-Guerrero, Julia Richter, René Scholtysik
Publikováno v:
Blood. 123(8)
The genetic hallmark of Burkitt lymphoma (BL) is the t(8;14)(q24;q32) and its variants leading to activation of the MYC oncogene. It is a matter of debate whether true BL without MYC translocation exists. Here, we identified 59 lymphomas concordantly
Autor:
Véronique Leblond, Peter G. Isaacson, Hongxiang Liu, Ming-Qing Du, José I. Martín-Subero, Frédéric Charlotte, Ahmet Dogan, Andrew Wotherspoon, Andrew G. Nicholson, Reiner Siebert, Ayoma D. Attygalle, Hongtao Ye, John R. Goodlad, Paul M. Speight, Anne Lavergne-Slove
Publikováno v:
Blood. 102(3)
t(11;18)(q21;q21) is a specific chromosomal translocation associated with mucosa-associated lymphoid tissue (MALT) lymphoma. It fuses the amino terminal of the API2 gene to the carboxyl terminal of the MALT1 gene and generates a chimeric fusion produ
Autor:
Ahmet Dogan, Ming-Qing Du, Renzo Ranaldi, Rifat Hamoudi, Peter G. Isaacson, Hongtao Ye, Italo Bearzi, Hongxiang Liu
Publikováno v:
Blood. 98(4)
The development of gastric mucosa-associated lymphoid tissue (MALT) lymphoma is a multistep process and can be clinico-pathologically divided into Helicobacter pylori-associated gastritis, low-grade tumors, and high-grade tumors. The molecular events
Publikováno v:
Scopus-Elsevier
A unique B-cell non-Hodgkin's lymphoma (NHL) cell line (Karpas 422), bearing both t(14;18) and t(4;11) chromosomal translocations as well as several other chromosomal abnormalities, has been established from the pleural effusion of a patient with che
Autor:
David Simpson, Masa Lasica, Jane Huang, Stephen Opat, Peter Browett, Alejandro Arbelaez, James Hilger, Yiqian Fang, Constantine S. Tam, Emma Verner, Chan Yoon Y. Cheah, Jacob D. Soumerai
Publikováno v:
Blood. 138:1419-1419
Background: BCL2, a key regulator of apoptosis, is aberrantly expressed in many hematologic malignancies, which can lead to pathologic cancer cell survival. BCL2 inhibitors have been shown to be safe and effective, resulting in their approval for the