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Publikováno v:
Europe PubMed Central
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Thioredoxin (Trx) is a ubiquitous protein disulfide oxidoreductase with antioxidant, cytokine, and chemotactic properties. Previously, we showed that Trx, in synergy with interleukin 1 (IL-1), IL-2, IL-4, tumor necrosis factor alpha (TNF-alpha), and
Autor:
Nicole Casadevall, Françoise Wendling, Stéphane Giraudier, Jean-Pierre Le Couedic, André Katz, William Vainchenker, Anne Laure Taksin, Najet Debili, Aline Massé, Isabelle Dusanter-Fourt
Publikováno v:
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Essential thrombocythemia (ET) and idiopathic myelofibrosis (PMF) are two myeloproliferative diseases characterized by a marked megakaryocytic (MK) involvement. The pathogenesis of these two diseases is unknown. Recently it has been shown that overex
Autor:
Katja Zirlik, Konrad Aumann, Dietmar Pfeifer, Rudolf Übelhart, Meike Burger, Julia Schüler, Niuscha Yaktapour, Christine Dierks, Hendrik Veelken, Tilman Brummer, Hassan Jumaa
Publikováno v:
Blood, 122(9), 1621-1633
The receptor tyrosine kinase (RTK) insulin-like growth factor-1 receptor (IGF1R) is implicated in various tumor entities including chronic lymphocytic leukemia (CLL), but its functional significance in this disease remains poorly characterized. Here,
Autor:
Claude Jasmin, M.C. Le Bousse-Kerdilès, S Chevillard, N Romquin, B Dupriez, MC Martyre, Florence Smadja-Joffe, Vincent Praloran, JL Demory, Denis Clay, A Charpentier
Publikováno v:
Europe PubMed Central
Myelofibrosis with myeloid metaplasia (MMM) is a myeloproliferative disorder characterized by clonal expansion of hematopoiesis and marrow fibrosis. Previous results from our group have shown an increased production of two potent fibrogenic factors a
Autor:
Morton Coleman, Lasika Seneviratne, Emil T. Kuriakose, Moshe Yair Levy, Jeffrey P. Letzer, S. Elkins, Jessica Rine, Vincent L. Hansen, Marina White
Publikováno v:
Blood. 126:3027-3027
Introduction: Panobinostat (PAN) is a potent pan-deacetylase inhibitor that targets multiple myeloma (MM) cells via its effects on epigenetics and protein metabolism. In the PANORAMA 1 phase 3 trial, the combination of PAN, bortezomib (BTZ), and dexa
Autor:
Suparna Mazumder, Sayer Al-Harbi, Lisa Rybicki, Jaroslaw P. Maciejewski, Gaurav S. Choudhary, Brian T. Hill, Janet A. Houghton, Kamini Singh, Alexandru Almasan, Matt Kalaycio, Jennifer DeVecchio
Publikováno v:
Blood. 118(13)
The antiapoptotic BCL-2 proteins regulate lymphocyte survival and are over-expressed in lymphoid malignancies, including chronic lymphocytic leukemia. The small molecule inhibitor ABT-737 binds with high affinity to BCL-2, BCL-XL, and BCL-W but with
Publikováno v:
Blood. 117(1)
Homoharringtonine (HHT) is a plant alkaloid that inhibits the elongation phase of translation that is currently in clinical trials. Because the intrinsically short-lived antiapoptotic protein myeloid cell leukemia-1 (Mcl-1) has been reported to suppo
Autor:
Sanne Lugthart, Lucy Skrabanek, Maria E. Figueroa, Stefan Meyer, Eric M.J. Bindels, Claudia A.J. Erpelinck-Verschueren, Yushan Li, Ari Melnick, Peter J. M. Valk, Ruud Delwel, Bob Löwenberg, John M. Greally
Publikováno v:
Blood, 117(1), 234-241. American Society of Hematology
DNA methylation patterns are frequently dysregulated in cancer, although little is known of the mechanisms through which specific gene sets become aberrantly methylated. The ecotropic viral integration site 1 (EVI1) locus encodes a DNA binding zinc-f
Autor:
Mercè de Frias, Joan Gil, Antonio F. Santidrian, Ana M. Cosialls, Benoit Viollet, Eva González-Barca, Llorenç Coll-Mulet, Diana M. González-Gironès, Verena Labi, Daniel Iglesias-Serret, Gabriel Pons, Clara Campàs, Andreas Villunger, Esther Alonso, Adalberto Benito
Publikováno v:
Blood. 116(16)
5-Aminoimidazole-4-carboxamide riboside or acadesine (AICAR) induces apoptosis in chronic lymphocytic leukemia (CLL) cells. A clinical study of AICAR is currently being performed in patients with this disease. Here, we have analyzed the mechanisms in
Autor:
Alvaro Aguayo, Charles Koller, Susan O'Brien, Miloslav Beran, Bart Barlogie, Hagop M. Kantarjian, Taghi Manshouri, Michael J. Keating, Cristi Gidel, Maher Albitar
Publikováno v:
Blood. 96:768-770
Strong evidence exists for an association between high vascular endothelial growth factor (VEGF) levels and poor prognoses in patients with solid tumors and acute leukemia. Using Western blot analysis and solid-phase radioimmunoassay, we measured cel