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of 31
pro vyhledávání: ''
Autor:
Isabelle S. Csete, Ross L. Levine, Qi Gao, Alexander Chan, Andriy Derkach, Maximilian Stahl, Sheng F. Cai, Jinjuan Yao, Tanmay Mishra, Richard Koche, Sophia Yanis, Martin S. Tallman, Aaron D Goldberg, Michael R. Waarts, Raajit K. Rampal, Ahmet Dogan, Robert L. Bowman, Minal Patel, Ying Liu, Wenbin Xiao, Mikhail Roshal, Maria E. Arcila, Jeeyeon Baik, Nicole L. DelGaudio, Christopher Famulare, Yanming Zhang
Publikováno v:
Blood
Plasmacytoid dendritic cells (pDCs) are the principal natural type I interferon–producing dendritic cells. Neoplastic expansion of pDCs and pDC precursors leads to blastic plasmacytoid dendritic cell neoplasm (BPDCN), and clonal expansion of mature
Autor:
Pablo Fresia, Jan A. Burger, Catalina Berca, Angimar Uriepero, Javier M. Di Noia, Pablo Elías Morande, Mariela Sivina, Ana Inés Landoni, Pablo Oppezzo, Noé Seija
Publikováno v:
Blood
Activation-induced cytidine deaminase (AID) initiates somatic hypermutation and class switch recombination of the immunoglobulin genes. As a trade-off for its physiological function, AID also contributes to tumor development through its mutagenic act
Autor:
Wolfgang R. Sperr, Susanne Herndlhofer, Tessa L. Holyoake, Katharina Blatt, Christine Mannhalter, Sabine Cerny-Reiterer, Michael Willmann, Thomas Rülicke, Gregor Hoermann, Gabriele Stefanzl, Irina Sadovnik, Peter Valent, Matthias Mayerhofer, Harald Herrmann, Martin Bilban, Berthold Streubel
Publikováno v:
Blood. 123:3951-3962
Chronic myeloid leukemia (CML) is a stem cell (SC) neoplasm characterized by the BCR/ABL1 oncogene. Although mechanisms of BCR/ABL1-induced transformation are well-defined, little is known about effector-molecules contributing to malignant expansion
Autor:
Domenica Saul, Andreas D. Hofmann, Regina Jitschin, Heiko Bruns, Jana Berger, Andreas Giessl, Michael J. Eckart, Juliane Bricks, Dimitrios Mougiakakos, Andreas Mackensen
Publikováno v:
Blood. 123:2663-2672
Alterations of cellular metabolism represent a hallmark of cancer. Numerous metabolic changes are required for malignant transformation, and they render malignant cells more prone to disturbances in the metabolic framework. Despite the high incidence
Autor:
Ya-Huei Kuo, Ravi Bhatia, Hongjun Liu, Yin Wei Ho, Tinisha McDonald, Stephen J. Forman, Cedric Dos Santos, Allen Lin
Publikováno v:
Blood. 122:1900-1913
The SRC family kinases (SFKs) and the receptor tyrosine kinase c-Kit are activated in human acute myeloid leukemia (AML) cells. We show here that the SFKs LYN, HCK, or FGR are overexpressed and activated in AML progenitor cells. Treatment with the SF
Autor:
Anna Cabrelle, Renato Zambello, Veronica Martini, Federica Frezzato, Antonella Teramo, Elisa Boscaro, Livio Trentin, Francesco Piazza, Cristina Gattazzo, Elisa Ave, Valentina Trimarco, Francesca Passeri, Albana Lico, Monica Facco, Gianpietro Semenzato, Giulia Tasca
Publikováno v:
Blood. 121:3843-3854
The JAK/STAT pathway is altered in T-cell large granular lymphocytic leukemia. In all patients, leukemic LGLs display upregulation of phosphorylated STAT3 (P-STAT3) that activates expression of many antiapoptotic genes. To investigate the mechanisms
Autor:
Xueqing Liang, Daniel J. Weisdorf, Veronika Bachanova, Michael A. Farrar, Bruce R. Blazar, E. Ashley Moseman, Wei Chen
Publikováno v:
Blood. 115:5041-5052
Chronic lymphocytic leukemia (CLL) is the most prevalent human leukemia and is characterized by the progressive accumulation of long-lived malignant B cells. Here we show that human B-CLL cells selectively express high levels of Toll-like receptor 9
Publikováno v:
Blood. 114:5201-5205
Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by proliferation of one or more myeloid cell lineages. Some patients exhibit leukemic transformation (LT) by unknown mechanisms, and chemotherapy may incre
Autor:
Quentin Liu, Yi-Xin Zeng, Fei Meng Zheng, Li Hui Wang, Xue Fei Huang, Juan Li, Xian Ren Wang, Xiang Bo Wan, Min Yan, Duo Rong Xu, Shao Kai Luo, Jie Xu
Publikováno v:
Blood. 111:2854-2865
Previously, we and others showed that mitotic Aurora-A kinase (Aur-A) was required for accurate mitotic entry and proper spindle assembly. In this study, we found that expression ofAur-Awas markedly elevated in bone marrow mononuclear cells (BMMCs) o
Autor:
Karoline V. Gleixner, Puchit Samorapoompichit, Christian Sillaber, Eva Jaeger, Hideaki Nakamura, Winfried F. Pickl, Khaled Greish, Gregor Hoermann, Harald Esterbauer, Julia Mayerhofer, Ilse Schwarzinger, Hiroshi Maeda, Karl J. Aichberger, Sophia Derdak, Rene G. Ott, Peter Valent, Veronika Sexl, Matthias Mayerhofer
Publikováno v:
Blood. 111:2200-2210
Resistance toward imatinib and other BCR/ABL tyrosine kinase inhibitors remains an increasing clinical problem in the treatment of advanced stages of chronic myeloid leukemia (CML). We recently have identified the heat shock protein 32 (Hsp32)/heme o