Zobrazeno 1 - 10
of 10
pro vyhledávání: ''
Autor:
Laurence Kraus-Berthier, Lucie Laplane, Véronique Saada, Céline Berthon, Maria E. Figueroa, Bouchra Badaoui, Margaux Sevin, Franck Debeurme, Eric Padron, Thorsten Braun, Qin Yang, Nathalie Droin, Raphael Itzykson, Guido Kroemer, Dorothée Selimoglu-Buet, Eric Solary, Oliver Kepp, Margot Morabito, Alix Derreal, Hannah Newman, Sylvain Thepot, Gabriel Etienne, Miguel Torres-Martin, Sébastien Banquet, Severine Badel, Orianne Wagner-Ballon, Pierre Fenaux
Publikováno v:
Blood
Blood, American Society of Hematology, 2021, 137 (24), pp.3390-3402. ⟨10.1182/blood.2020008729⟩
Blood, American Society of Hematology, 2021, 137 (24), pp.3390-3402. ⟨10.1182/blood.2020008729⟩
Mouse models of chronic myeloid malignancies suggest that targeting mature cells of the malignant clone disrupts feedback loops that promote disease expansion. Here, we show that in chronic myelomonocytic leukemia (CMML), monocytes that accumulate in
Autor:
Satoshi Yamashita, Naoko Hattori, Yuki Kurahashi, Toshikazu Ushijima, Naoko Sueoka-Aragane, Tatsuro Watanabe, Akemi Sato, Kensuke Kojima, Hideaki Nakamura, Atsushi Kawaguchi, Shinya Kimura, Eisaburo Sueoka, Nao Yoshida, Kazuharu Kamachi, Seiji Okada, Hiroshi Ureshino, Yuki Fukuda-Kurahashi
Publikováno v:
Blood. 136:871-884
Adult T-cell leukemia-lymphoma (ATL) is an aggressive hematological malignancy of CD4+ T cells transformed by human T-cell lymphotropic virus-1 (HTLV-1). Most HTLV-1–infected individuals are asymptomatic, and only 3% to 5% of carriers develop ATL.
Autor:
Ming Hou, Fangmiao Jing, Yang Liu, Tao Sun, Yajing Zhao, Hong-yu Zhao, Yu Hou, Hai Zhou, Lizhen Li, Ya-hui Ma, Panpan Han, Xinguang Liu, Ping Li, Jun Peng, Daqi Li
Publikováno v:
Blood. 133:730-742
Increased macrophage phagocytosis of antibody-coated platelets, as well as decreased numbers and/or impaired function of CD4+CD25+Foxp3+ regulatory T (Treg) cells, has been shown to participate in the pathogenesis of immune thrombocytopenia (ITP). Lo
Autor:
Tomomitsu Miyagaki, Tomonori Oka, Rina Nakajima, Shinichi Sato, Hiraku Suga, Hiroaki Kamijo, Makoto Sugaya, Naomi Shishido-Takahashi
Publikováno v:
Blood. 132:1922-1935
CD137 and its ligand, CD137L, are expressed on activated T cells and antigen-presenting cells, respectively. Recent studies have shown that CD137L and CD137 are aberrantly expressed by tumor cells, especially in some hematopoietic malignancies, and i
Autor:
Jiajing Qiu, John Mascarenhas, Xiaoli Wang, Wioleta Kowalczyk, Cing Siang Hu, Netonia Marshall, Anna Tarasova, Tianbo Jiang, Goar Mosoyan, Wu He, Ronald Hoffman, David A. Winkler, Joshua Brody, David N. Haylock
Publikováno v:
Blood. 127:3398-3409
Recently, interactions between thrombopoietin (TPO) and its receptor, the myeloproliferative leukemia (MPL) virus oncogene, have been shown to play a role in the development and progression of myeloproliferative neoplasms including myelofibrosis (MF)
Autor:
Véronique Leblond, Thérèse Aurran-Schleinitz, Richard Lemal, Mathilde Hunault, Anne Wanquet, Rudy Birsen
Publikováno v:
Blood. 127:2356-2358
To the editor: Central nervous system involvement (CNSi) is a rare complication in chronic lymphocytic leukemia (CLL).[1][1][⇓][2]-[3][3] Neither prognostic factors nor consensual therapeutic management guidelines are available. Multiple therapies
Autor:
Christopher J. Patterson, Nicholas Tsakmaklis, Toni Dubeau, Richard R. Furman, Zachary R. Hunter, Lian Xu, M. Lia Palomba, Guang Yang, Xia Liu, Joshua Gustine, Amanda Kofides, Jorge J. Castillo, Steven P. Treon, Kirsten Meid, Jiaji G. Chen, Maria Demos, Ranjana H. Advani
Publikováno v:
Blood
Ibrutinib produces high response rates and durable remissions in Waldenström macroglobulinemia (WM) that are impacted by MYD88 and CXCR4(WHIM) mutations. Disease progression can develop on ibrutinib, although the molecular basis remains to be clarif
Rational targeted therapies to overcome microenvironment-dependent expansion of mantle cell lymphoma
Autor:
Martine Amiot, Antonin Papin, Steven Le Gouill, Benoit Tessoulin, Selina Chen-Kiang, Julie Esbelin, Philippe Moreau, David Chiron, Cyrille Touzeau, Catherine Pellat-Deceunynck, Celine Bellanger, Valérie Trichet, Anne Moreau, Christelle Dousset, Sophie Maïga
Publikováno v:
Blood. 128(24)
Mantle cell lymphoma (MCL) accumulates in lymphoid organs, but disseminates early on in extranodal tissues. Although proliferation remains located in lymphoid organs only, suggesting a major role of the tumor ecosystem, few studies have assessed MCL
Autor:
Ralph V. Boccia, Dawn E. Pinchasik, Richy Agajanian, Paul Conkling, Amy S. Kimball, Alberto Bessudo, Hui Yang, Wael A. Harb, James R. Berenson
Publikováno v:
Blood. 128:3325-3325
Introduction: Carfilzomib is an irreversible second-generation proteasome inhibitor that is currently approved for the treatment of relapsed or refractory multiple myeloma (MM). The primary objective of the CHAMPION-2 study was to determine the maxim
Autor:
Sara Dellasala, Prajwal Boddu, Naval Daver, Elias Jabbour, Steven M. Kornblau, Tapan M. Kadia, Srdan Verstovsek, Sherry Pierce, Abdul Rashid Shah, Gautam Borthakur, Hagop M. Kantarjian, Jan A. Burger, Jorge E. Cortes, Ahmad Alhuraiji, Guillermo Garcia-Manero, Farhad Ravandi, Nitin Jain
Publikováno v:
Blood. 128:3073-3073
INTRODUCTION: Ponatinib is a pan-tyrosine kinase inhibitor (TKI) with proven efficacy in multi-refractory CML patients (pts) who have failed other TKIs and approved in all CML stages after failure to other TKIs and for pts with T315I mutation. Despit