Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Jiang A"'
Autor:
Sha Song, Chen'ao Qian, Xiaofeng Xue, Qi Su, Huiying Han, Gao Fan, Wenzhuo Zhuang, Yunxin Jiang, Weimin Zhang, Bingzong Li
Publikováno v:
Blood. 137:1603-1614
The initiation and progression of diffuse large B-cell lymphoma (DLBCL) is governed by genetic and epigenetic aberrations. As the most abundant eukaryotic messenger RNA (mRNA) modification, N6-methyladenosine (m6A) is known to influence various funda
Autor:
Zijun Song, Ronggui Hu, Junxia Min, Cong Yang, Fudi Wang, Kai Wang, Enjun Xie, Jiaming Wang, Yueyang Zhong, Pu Ni, Yingying Yu, Hao Wang, Qian Wu, Li Jiang
Publikováno v:
Blood
Ferroportin (FPN), the only known cellular iron exporter, plays a central role in intracellular and systemic iron homeostasis, and its levels are regulated by hepcidin. Using genetic screens and models, Jiang and colleagues identified an E3 ubiquitin
Autor:
Katharina Rothe, Artem Babaian, Keith Keith Humphries, Jonathan Zeng, Xiaoyan Jiang, Min Chen, Donna L. Forrest, Hanyang Lin, Oleh Petriv, Inanc Birol, Connie J. Eaves, Jens Ruschmann, Tobias Maetzig, Ryan R. Brinkman, David J.H.F. Knapp, Naoto Nakamichi, Kieran O'Neill, Carl L. Hansen, Ryan Yen, Andrew Wu
Publikováno v:
Blood
Overcoming drug resistance and targeting cancer stem cells remain challenges for curative cancer treatment. To investigate the role of microRNAs (miRNAs) in regulating drug resistance and leukemic stem cell (LSC) fate, we performed global transcripto
Autor:
Yizhou Jiang, Abhinav Deol, Lianqing Zheng, Sattva S. Neelapu, Jenny J. Kim, Nancy L. Bartlett, John M. Rossi, Ira Braunschweig, Olalekan O. Oluwole, Javier Munoz, David B. Miklos, Caron A. Jacobson, Frederick L. Locke
Publikováno v:
Blood. 135:2106-2109
Neelapu and colleagues report a post hoc subgroup analysis from the ZUMA-1 trial of chimeric antigen receptor T-cell therapy for relapsed or refractory diffuse large B cell lymphoma. In comparison with younger patients, those ≥65 years old have sim
Autor:
Joe Salas, Tongyao Liu, Randy Mauldin, Jiayun Liu, Terrence M. Dobrowsky, Jurg M. Sommer, Volker Schellenberger, Susannah Patarroyo-White, Mark Tie, Ayman Ismail, Buyue Yang, Haiyan Jiang, Arjan van der Flier, Qi Lu, Chris Furcht, Nancy Moore, Tyler Carlage, John Kulman, Baisong Mei, Amy M Holthaus, Allison Goodman, Zhan Liu, Lily Zhu, Robert T. Peters, Deana Rabinovich, Glenn F. Pierce, Ekta Seth Chhabra, Douglas Drager, Oblaise Mercury, Zhiqian Liu
Publikováno v:
Blood
Factor VIII (FVIII) replacement products enable comprehensive care in hemophilia A. Treatment goals in severe hemophilia A are expanding beyond low annualized bleed rates to include long-term outcomes associated with high sustained FVIII levels. Endo
Autor:
Kiyomi Morita, Koichi Takahashi, Yajian Jiang, Tianyuan Hu, Matthew C. Hill, Ayumi Kitano, Feng Wang, Xizeng Mao, Yusuke Saito, James F. Martin, Kevin A. Hoegenauer, P. Andrew Futreal, Daisuke Nakada, Kazuhiro Morishita
Publikováno v:
Blood
Oncogenic mutations confer on cells the ability to propagate indefinitely, but whether oncogenes alter the cell fate of these cells is unknown. Here, we show that the transcriptional regulator PRDM16s causes oncogenic fate conversion by transforming
Autor:
Steven J. Schrodi, Peng An, Minghua Wang, Robert Strenn, Narendranath Epperla, Wenyu Wu, Terrie Kitchner, Fudi Wang, Jiucun Wang, Jennifer K. Meece, Joseph J. Mazza, Zhan Ye, Mehdi Maadooliat, Shuai Jiang, Jeffrey Joyce, Yanyun Ma, Brent F. Olson, Shicheng Guo, Judith A. Smith, Li Jin
Publikováno v:
Blood. 133:1888-1898
Standard analyses applied to genome-wide association data are well designed to detect additive effects of moderate strength. However, the power for standard genome-wide association study (GWAS) analyses to identify effects from recessive diplotypes i
Autor:
Danna Jia, Zhaohui Tang, Jingzhen Li, Tao Jiang, Xiliang Liu, Shanshan Yu, Qing Kenneth Wang, Yunqiao Han, Zhen Qu, Xuebin Hu, Shanglun Xie, Yuwen Huang, Yuexia Lv, Daji Luo, Yayun Qin, Fei Liu, Zhaojing Lu, Shanshan Han, Mugen Liu, Jiayi Tu, Yuntong Zhao
Publikováno v:
Blood. 133:805-815
Hematopoietic stem and progenitor cells (HSPCs) originate from the hemogenic endothelium via the endothelial-to-hematopoietic transition, are self-renewing, and replenish all lineages of blood cells throughout life. BCAS2 (breast carcinoma amplified
Autor:
Joseph M. Connors, Jeffrey W. Craig, Pedro Farinha, Graham W. Slack, Kerry J. Savage, Brett Collinge, Ryan D. Morin, Diego Villa, Aixiang Jiang, Lauren C. Chong, Tomoko Miyata-Takata, David W. Scott, Elizabeth A. Chavez, Anja Mottok, Daisuke Ennishi, Andrew J. Mungall, Laurie H. Sehn, Randy D. Gascoyne, Susana Ben-Neriah, Barbara Meissner, Marco A. Marra, Ciara L. Freeman, Alina S. Gerrie, Merrill Boyle, Christian Steidl
Publikováno v:
Blood.
When the World Health Organization defined high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) as a clinical category, rearrangements were the only structural variant (SV) incorporated. An "atypical double-hit" catego
Autor:
Marta Isidro-Hernández, Verónica Domínguez, Xiaoyu Jiang, Belén Pintado, Diego Alonso-López, Yaso Natkunam, Javier Raboso-Gallego, Ana Casado-García, Carolina Vicente-Dueñas, Oscar Blanco, Shuchun Zhao, Andrew J. Gentles, Isidro Sánchez-García, Izidore S. Lossos, Javier De Las Rivas
Publikováno v:
Blood
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
Diffuse large B-cell lymphomas (DLBCLs) are clinically and genetically heterogeneous tumors. Deregulation of diverse biological processes specific to B cells, such as B-cell receptor (BCR) signaling and motility regulation, contribute to lymphomagene