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Publikováno v:
Bioscience Reports
Cyclin dependent kinase inhibitor 2A (CDKN2A) is an essential regulator of immune cell functionality, but the mechanisms whereby it drives immune infiltration in hepatocellular carcinoma (HCC) remain unclear. In the present study, we studied the asso
Autor:
Yuhua Zhang
Publikováno v:
Bioscience Reports
The pathogenesis of diabetic nephropathy (DN) has not been fully elucidated. MicroRNAs (miRNAs) play an important role in the onset and development of DN renal fibrosis. Thus, the present study aimed to investigate the effect of miR-92d-3p on the pro
Publikováno v:
Bioscience Reports
Acute coronary syndrome (ACS) results from inadequate supply of blood flow from the coronary arteries to the heart or ischemia. ACS has an extremely high morbidity and mortality. The levels of biomarkers currently used for detection of ACS also incre
Publikováno v:
Bioscience Reports
It has been demonstrated that trimethylamine N-oxide (TMAO) serves as a driver of atherosclerosis, suggesting that reduction of TMAO level might be a potent method to prevent the progression of atherosclerosis. Herein, we explored the role of TMAO in
Publikováno v:
Bioscience Reports
Background. Coronary artery disease (CAD) is a chronic inflammatory disease caused by development of atherosclerosis (AS), which is the leading cause of mortality and disability. Our study aimed to identify the differentially expressed genes (DEGs) i
Publikováno v:
Bioscience Reports
To facilitate temperature adjustments, the testicles are located outside the body cavity. In most mammals, the temperature of the testes is lower than the body temperature to ensure the normal progression of spermatogenesis. Rising temperatures affec
Autor:
Karam Mosallam, Sawsan Abuhamdah, Bakheet E. M. Elsadek, Mohammed M Wahman, Tarek Hamdy Abd-Elhamid, Morris Beshay, Mohammed H. Hassan, Mohamed Abdel-Bary
Publikováno v:
Bioscience Reports
Background: Survivin is a common member of the inhibitors of the apoptosis protein (IAP) family and promoter of cell proliferation. Fibulin-3 is a matrix glycoprotein with a potential for tumor suppression or propagation. The aim of this study was to
Publikováno v:
Bioscience Reports
Millions of people infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been diagnosed with coronavirus infectious disease 2019 (COVID-19). The prevalence and severity of COVID-19 differ between sexes. To explain these differ
Publikováno v:
Bioscience Reports
Background: Lung adenocarcinoma (LUAD) is a heterogeneous disease with high mortality. Close attention has been paid to immunotherapy in LUAD treatment. However, immunotherapy has produced different therapeutic effects because of immune heterogeneity
Publikováno v:
Bioscience Reports
To clarify the mechanism of circGOLPH3 regulation on prostate cancer cells, we performed an overexpression and interference circGOLPH3 assay in prostate cancer cells PC-3 and then evaluated cellular viability, proliferation, cell cycle, and apoptosis