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Autor:
Zeng-Lei Zhang, Yan-Yan Xu, Zhen Qin, Yong-Zheng Lu, Tian-Ding Liu, Li Zhang, Jia-Hong Shangguan, Wei Wang, Jun-Nan Tang, Jin-Ying Zhang
Publikováno v:
Bioscience Reports
Background: Although numerous studies have suggested that elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) is positively correlated with cardiovascular events, especially the heart failure and heart failure-related death (HFRD), evidence
Publikováno v:
Bioscience Reports
Background: Emerging evidence shows that m.5178C>A variant is associated with a lower risk of coronary artery disease (CAD). However, the specific mechanisms remain elusive. Since dyslipidemia is one of the most critical risk factors for CAD and acco
Publikováno v:
Bioscience Reports
Background: Stargardt disease (STGD) is the most common form of juvenile macular dystrophy associated with progressive central vision loss, and is agenetically and clinically heterogeneous disease. Molecular diagnosis is of great significance in aidi
Publikováno v:
Bioscience Reports
Background: Hepatocellular carcinoma (HCC) is a common fatal malignant tumor worldwide. Signal transducer and activator of transcription 4 (STAT4) is HCC susceptibility gene identified by genome-wide association study. The purpose of the present stud
Publikováno v:
Bioscience Reports
Marfan syndrome (MFS) is a dominant monogenic disease caused by mutations in fibrillin 1 (FBN1). Cardiovascular complications are the leading causes of mortality among MFS. In the present study, a whole-exome sequencing of MFS in the Chinese populati
Autor:
Hanqing Tang, Sheng Yang, Yingan Chen, Caiping Liu, Geyu Liang, Xiaomei Zhang, Yun Zhou, Xiaoling Kong
Publikováno v:
Bioscience Reports
Objective: Gastric cancer is the most common gastrointestinal malignancy in China and results from a combination of genetic and environmental factors. The present study was conducted to investigate the relationship between long noncoding RNA (lncRNA)
Publikováno v:
Bioscience Reports
Background: Genome-wide linkage analysis revealed the polymorphism of rs6748040 and glutamic acid repeat are potential pathogenic factors of early-onset myocardial infarction (MI). The present study was designed to investigate the associations of Als
Publikováno v:
Bioscience Reports
It is believed that an individual’s hereditary factors may be involved in the development of esophageal cancer (EC). The present study recruited 721 esophageal squamous cell carcinoma (ESCC) cases and 1208 controls and explored the roles of single
Autor:
Bang-Dang Chen, Yang Li, Yong-Tao Wang, Min-Tao Gai, Yi-Ning Yang, Dilare Adi, Yi-Tong Ma, Jialin Abuzhalihan, Zhen-Yan Fu, Xiang Xie, Xiang Ma, Fen Liu, Xiao-Mei Li
Publikováno v:
Bioscience Reports
Hyperlipidemia is one of the main risk factors for coronary artery disease (CAD). In the present study, we aimed to explore whether the single-nucleotide polymorphisms (SNPs) in amyloid precursor-like protein (APLP) 2 (APLP2) gene were associated wit
Autor:
Lanlan Wang, Xu Chao, Qing Zha, Xuesong Feng, Hailong Shi, Yanni Chen, Yuewen Wang, Haiyu Shen, Chao Jiang
Publikováno v:
Bioscience Reports
Numerous evidence has revealed that single-nucleotide polymorphisms (SNPs) are associated with liver cancer risk. To assess whether the MIR17HG polymorphisms are associated with the liver cancer risk in the Chinese Han population, we performed a case