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Autor:
Saja B Alzughoul, Hala T Abu Kassab, Ayat J Abu Shameh, Mohammad K Alhazabreh, Sana'a A Jaber, Amani D Abu Kwiak, Salam S Abu Laila, Mays M Jaradat, Nour M Al-Daoud, Mo'tasem M Alsmadi
Publikováno v:
Biopharmaceutics & Drug Disposition. 42:263-284
Renal (RIP) and hepatic (HIP) impairments are prevalent conditions in cancer patients. They can cause changes in gastric emptying time, albumin levels, hematocrit, glomerular filtration rate, hepatic functional volume, blood flow rates, and metabolic
Autor:
Pedro Eduardo Fröehlich, Flavio Pechanksy, Graciela Carlos, Fabiano Barreto, Renata Pereira Limberger, Eloisa Comiran
Publikováno v:
Biopharmaceutics & Drug Disposition. 42:3-11
Lisdexamfetamine (LDX) is a long-acting prodrug stimulant indicated for the treatment of attention-deficit/hyperactivity disorder (ADHD) and binge-eating disorder (BED) symptoms. In vivo hydrolysis of the LDX amide bond releases the therapeutically a
Publikováno v:
Biopharmaceutics & Drug Disposition. 41:126-148
Calcitriol or 1,25-dihydroxyvitamin D3 [1,25(OH)2 D3 ] is the active ligand of the vitamin D receptor (VDR) that plays a vital role in health and disease. Vitamin D is converted to the relatively inactive metabolite, 25-hydroxyvitamin D3 [25(OH)D3 ],
Publikováno v:
Biopharmaceutics & Drug Disposition. 41:44-53
Affecting the absorption of active ingredients in the intestine serves as one of the important compatibility mechanisms of traditional Chinese medicine. The aim of this study was to investigate the compatibility mechanism of ShengDiHuang Decoction (S
Autor:
Ayuko Kondo, Katsuya Narumi, Masaki Kobayashi, Keisuke Okuhara, Ken Iseki, Yuka Takahashi, Ayako Furugen
Publikováno v:
Biopharmaceutics & Drug Disposition. 40:302-306
Theaflavins (TFs) are derived from black tea, an important source of dietary polyphenols. Although the potential interactions between dietary polyphenols and drugs have been demonstrated through in vitro and in vivo studies, little information is ava
Autor:
Tetsuya Hayashi, Ryuji Kato, Takaji Sato, Shoichi Yoshikai, Satomi Nakashiro, Yoshiki Mino, Yoshio Ijiri, Hideki Imano, Taku Yamazaki, Asuka Iwamoto, Ayumi Fujimoto, Kazuhiko Tanaka, Masahiko Chikuma
Publikováno v:
Biopharmaceutics & Drug Disposition. 40:242-249
The protein binding rates (PBR) of platinum-containing agents cisplatin (CDDP), carboplatin (CBDCA) and oxaliplatin (L-OHP) have been reported as 98%, 25-50% and 98%, respectively. To investigate the protein-binding properties of albumin with cisplat
Publikováno v:
Biopharmaceutics & Drug Disposition. 40:44-48
Capecitabine is a 5-fluorouracil (5-FU) derivative that is used widely in the treatment of colorectal cancer. The plasma ratio of dihydrouracil (UH2 ) to uracil (Ura) is expected to gain relevance as an indirect-response biomarker to estimate the act
Publikováno v:
Biopharmaceutics & Drug Disposition. 40:3-11
Metformin is always used as the baseline antidiabetic therapy for patients with type 2 diabetes mellitus (T2DM) and hyperuricemia. Metformin is excreted into urine through active secretion mediated by rOCTs and rMATE1.The aim of this study was to ide
Autor:
Zhenxian Zhang, Phillip M. Gerk
Publikováno v:
Biopharmaceutics & Drug Disposition. 39:443-447
Phenylephrine (PE) has low and variable oral bioavailability in humans, due in part to presystemic metabolism by sulfation. LS180 cells were used as a model of the human intestinal epithelium to examine phenylephrine metabolism and its inhibition by
Autor:
Hui Zhou, Huidi Jiang, Su Zeng, Wang Wei, Liping Li, Jingqun Yuan, Meijuan Tu, Hongmei Lei, Weijuan Du
Publikováno v:
Biopharmaceutics & Drug Disposition. 39:411-419
Nuciferine (NF), one of the main and effective components in Nelumbo nucifera Gaertn. leaf extracts, is a promising drug candidate for the treatment of obesity-related diseases, while metformin is a first line therapeutic drug for type 2 diabetes mel