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Publikováno v:
Biopharmaceutics & Drug Disposition. 34:186-194
To better understand the factors that contribute to the accumulation of unmetabolized parabens (p-hydroxybenzoic acid esters) in breast cancer tissue, the binding of a series of parabens (methyl-, ethyl-, butyl-, benzyl-paraben) to human serum albumi
Autor:
Liesbeth Viaene, Ruben Poesen, Pieter Annaert, Henriette de Loor, Björn Meijers, Pieter Evenepoel
Publikováno v:
Biopharmaceutics & Drug Disposition. 34:165-175
Indoxyl sulfate and p-cresyl sulfate are two uremic retention solutes implicated in the uremic syndrome. Removal during dialysis is limited, mainly due to protein binding. Binding characteristics to healthy albumin have recently been characterized. W
Publikováno v:
Biopharmaceutics & Drug Disposition. 29:349-355
Gemfibrozil is a practically water-insoluble, high-dose drug. It represents a typical drug with dissolution rate controlled bioavailability. The aim of this study was to select a dissolution condition for gemfibrozil immediate release capsules, resul
Autor:
Kiminori Mohri, Yoshihiro Uesawa
Publikováno v:
Biopharmaceutics & Drug Disposition. 29:185-188
It has been reported that the intestinal absorption of celiprolol, an antihypertensive drug, is inhibited when it is taken with orange juice; it has been suggested that element(s) in citrus juice are responsible for this. In the present study, the ph
Autor:
Dae-Duk Kim, Do Yong Jeon, Sung Koun Heo, Min Koo Choi, Dong Soon Im, Jung Ju Kim, Yang Gyu Choi, Jeiwon Cho, Ji Woong Cheon, Chang-Koo Shim, Suk Jae Chung
Publikováno v:
Biopharmaceutics & Drug Disposition. 29:37-44
Ketoprofen plasters of 70 cm(2) size using DuroTak acrylic adhesive polymers were developed either containing 30 mg (Ketotop-L) or 60 mg drug (Ketotop-P). The in vitro skin permeation profile was obtained in hairless mouse skin and showed the permeat
Publikováno v:
Biopharmaceutics & Drug Disposition. 28:439-444
Phenazopyridine hydrochloride is a strong analgesic used in the treatment of urinary tract infections. The aim of the present study was to develop a procedure based on gas chromatography-mass spectrometry (GC-MS) for the analysis of phenazopyridine i
Publikováno v:
Biopharmaceutics & Drug Disposition. 27:17-21
The present study aims to investigate the intestinal absorption characteristics of ketoprofen in rats. The pharmacokinetic profile of ketoprofen was evaluated following a single p.o. administration of ketoprofen (1 mg/kg) to rats in the absence and p
Publikováno v:
Biopharmaceutics & Drug Disposition. 26:225-232
Ethosuximide is a chiral drug substance primarily indicated for the treatment of absence seizures. This drug is used clinically as the racemate. The human urinary metabolites of ethosuximide (I) have been studied using chiral gas chromatography (GC)
Publikováno v:
Biopharmaceutics & Drug Disposition. 21:303-311
The enantioselective disposition kinetics of the benzimidazole anthelmintic, ricobendazole (RBZ), have been characterized after its intravenous (iv) and subcutaneous (sc) administration as a racemic formulation to cattle. The (+) and (−) RBZ enanti
Autor:
Eun Lee, Myung Gull Lee, So H. Kim, Soon Hui Kim, Won B. Kim, Moohi Yoo, Hyun J. Shim, Jong W. Kwon
Publikováno v:
Biopharmaceutics & Drug Disposition. 21:285-291
Various factors influencing the protein binding of DA-8159 to 4% human serum albumin (HSA) were evaluated using an equilibrium dialysis technique at an initial DA-8159 concentration of 5 µg/mL. It took approximately 8 h incubation to reach an equili