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pro vyhledávání: '"Xiaorong Liang"'
Autor:
Xiaorong Liang, Weiru Wang, Zhongguo Wang, Alexandre J. Buckmelter, Bianca M. Liederer, Maureen Caligiuri, Nicholas J. Skelton, Karl H. Clodfelter, Yang Xiao, Leslie Wang, Timm Baumeister, Thomas O'Brien, Peter S. Dragovich, Nikolai Kley, Mark Zak, Jiansheng Wu, Xiaozhang Zheng, Yezhen Feng, Angela Oh, Hongxing Wu, Guangxing Yang, Kenneth W. Bair, Geeta Sharma, Dominic J. Reynolds, Krista K. Bowman, Chase C. Smith, Jian Lin, Yuen Po-Wai, Jason Oeh, Hong Li, Jarrod Tremayne, Deepak Sampath, Paul Bauer, Yen-Ching Ho, Bingsong Han, Justin Ly
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(20)
Potent, 1H-pyrazolo[3,4-b]pyridine-containing inhibitors of the human nicotinamide phosphoribosyltransferase (NAMPT) enzyme were identified using structure-based design techniques. Many of these compounds exhibited nanomolar antiproliferation activit