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Autor:
Thomayant Prueksaritanont, Christopher J. Winrow, John J. Renger, Susan L. Garson, Paul J. Coleman, John D. Schreier, Swati P. Mercer, Georgia B. McGaughey, Scott M. Doran, Anthony J. Roecker, George D. Hartman, C. Meacham Harrell, Christopher D. Cox, Cuyue Tang, Wayne B. Anderson, Duane R. Reiss
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(14)
Orexins are excitatory neuropeptides that regulate arousal and sleep. Orexin receptor antagonists promote sleep and offer potential as a new therapy for the treatment of insomnia. In this Letter, we describe the synthesis of constrained diazepanes ha