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pro vyhledávání: '"Roller A"'
Autor:
Erin Swiger, Thomas J. Rimele, Vincent Rash, David Moncol, Donald L. Hertzog, Caroline J. Diaz, Jon L. Collins, Christopher Nystrom, Pierette Banker, David J. Cowan, Channa K Jayawickreme, Josephine Yuen, Sean Ross, Shane Roller, Xi Liang, Steven M. Sparks, Christopher Joseph Aquino, Dock Steven Thomas, Grace Chen
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(5)
The long chain free fatty acid receptor 4 (FFA4/GPR120) has recently been recognized as lipid sensor playing important roles in nutrient sensing and inflammation and thus holds potential as a therapeutic target for type 2 diabetes and metabolic syndr
Autor:
Shane Roller, Cory R. Theberge, Harold G. Selnick, Rodney A. Bednar, Steven N. Gallicchio, Scott D. Mosser, John F. Fay, Joseph P. Vacca, Constantine Kreatsoulas, Eric L. Moore, C. Blair Zartman, Samuel L. Graham, Theresa M. Williams, Steven S. Sharik, Ian M. Bell, James C. Hershey, Craig A. Stump, Amy G. Quigley, Christopher A. Salvatore, Stefanie A. Kane, Richard Alexander Jelley
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(8)
A novel series of potent CGRP receptor antagonists containing a central quinoline ring constraint was identified. The combination of the quinoline constraint with a tricyclic benzimidazolinone left hand fragment produced an analog with picomolar pote