Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lei Chen"'
Autor:
Bin Hu, Ling Tong, Sony Agrawal, Craig A. Coburn, Bandarpalle B. Shankar, Michael P. Dwyer, Bin Zhong, Lei Chen, Shiying Chen, Seong Heon Kim, Stuart B. Rosenblum, Shuai Zan, Karin Bystol, Ian W. Davies, Donna Carr, Ernest Asante-Appiah, Wensheng Yu, Joseph A. Kozlowski, Rebecca T. Ruck, Patricia McMonagle, Anilkumar G. Nair, Rong Liu, Oleg Selyutin, De-Yi Yang, Paul Ingravallo, Tao Ji, Qingbei Zeng, Jinglai Hao, Stephanie Curry, Frederick C. Lahser
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(21)
We describe the impact of proline modifications, in our tetracyclic-indole based series of nonstructural protein 5A (NS5A) inhibitors, to their replicon profiles. This work identified NS5A inhibitors with an improved and flattened resistance profiles
Autor:
Rong Kong, Wensheng Yu, Paul Ingravallo, Bin Hu, Ling Tong, Richard Soll, Joseph A. Kozlowski, Stuart B. Rosenblum, Rong Liu, James I. Fells, Ellen Xia, Oleg Selyutin, Craig A. Coburn, Peter T. Meinke, Sony Agrawal, Lei Chen, Amin A. Nomeir, Bin Zhong, Ernest Asante-Appiah, Michael P. Dwyer, Anilkumar G. Nair, Ying Zhai, Yueheng Jiang
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(20)
Herein, we describe our research efforts to develop unique cores in molecules which function as HCV nonstructural protein 5A (NS5A) inhibitors. In particular, various fused tetracyclic cores were identified which showed genotype and mutant activities
Autor:
Guowei Zhou, Ling Tong, Bandarpalle B. Shankar, De-Yi Yang, Rong Liu, Sony Agrawal, Ying Zhai, Rong Kong, Craig A. Coburn, Lei Chen, Qingbei Zeng, Seong Heon Kim, Brian J. Lavey, Kerry Keertikar, Razia Rizvi, Ellen Xia, Michael Wong, Yueheng Jiang, Stuart B. Rosenblum, Wensheng Yu, Ernest Asante-Appiah, Anilkumar G. Nair, Joseph A. Kozlowski, Paul Ingravallo, Amin A. Nomeir, Michael P. Dwyer, Oleg Selyutin
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(16)
A matched and mixed capping SAR study was conducted on the tetracyclic indole class of HCV NS5A inhibitors to examine the influence of modifications of this region on the overall HCV virologic resistance profiles.
Autor:
Patricia McMonagle, Sony Agrawal, Stuart B. Rosenblum, Ling Tong, Wensheng Yu, Paul Ingravallo, Bandarpalle B. Shankar, Guowei Zhou, Oleg Selyutin, Razia Rizvi, Bin Zhong, Frederick C. Lahser, Rong Liu, Brian J. Lavey, De-Yi Yang, Stephanie Curry, Craig A. Coburn, Laura Rokosz, Michael P. Dwyer, Joseph A. Kozlowski, Lei Chen, Amin A. Nomeir, Donna Carr, Ernest Asante-Appiah, Yueheng Jiang, Anilkumar G. Nair, Seong Heon Kim, Qingbei Zeng, Jinglai Hao, Michael Wong, Bin Hu
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(15)
HCV NS5A inhibitors have demonstrated impressive in vitro potency profiles in HCV replicon assays and robust HCV RNA titer reduction in the clinic making them attractive components for inclusion in an all oral fixed dose combination regimen for the t
Autor:
Jing Ren, Minbo Su, Jingkang Shen, Yue-Lei Chen, Wei Xu, Yi Zang, Danqi Chen, Jia Li, Le Tang, Bing Xiong, Yubo Zhou
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(18)
Menin is an essential oncogenic cofactor for mixed lineage leukemia (MLL)-mediated leukemogenesis, functioning through its direct interaction with MLL1 protein. Therefore, targeting the menin–MLL1 protein–protein interface represents a promising
Autor:
Ernest Asante-Appiah, Sony Agrawal, Peter T. Meinke, Ellen Xia, Anilkumar G. Nair, Joseph A. Kozlowski, Lei Chen, De-Yi Yang, Michael P. Dwyer, Craig A. Coburn, Oleg Selyutin, Michael Wong, Rong Kong, Bin Hu, George F Njoroge, Amin A. Nomeir, Tao Ji, Rong Liu, Paul Ingravallo, Ling Tong, Ying Zhai, Stuart B. Rosenblum, Yueheng Jiang, Wensheng Yu, James I. Fells, Bin Zhong, Kevin X. Chen, Qingbei Zeng
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(13)
HCV NS5A inhibitors have demonstrated impressive in vitro potency profiles in HCV replicon assays and robust HCV RNA titer reduction in the clinic making them attractive components for inclusion in an all oral fixed dose combination regimen for the t
Autor:
Ying Zhai, Ellen Xia, Lei Chen, Bandarpalle B. Shankar, Qingbei Zeng, Anilkumar G. Nair, Sony Agrawal, Ronald N. Buckle, Guowei Zhou, Kannan P. Naicker, John P. Caldwell, Ling Tong, Yueheng Jiang, Stuart B. Rosenblum, Wensheng Yu, Kerry Keertikar, Haiqun Tang, Seong Heon Kim, Rong Liu, De-Yi Yang, Paul Ingravallo, Gregory Scott Martin, Samuel A. Vellekoop, Melissa L. Allard, Christian L. Holst, Michael P. Dwyer, Amin A. Nomeir, Robert Mazzola, Polivina Jolicia F Gauuan, Joseph A. Kozlowski, Oleg Selyutin, Rong Kong
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(5)
HCV NS5A inhibitors have shown impressive in vitro potency profiles in HCV replicon assays thus making them attractive components for inclusion in an all oral fixed dose combination treatment regimen. Herein we describe the research efforts that led