Zobrazeno 1 - 4
of 4
pro vyhledávání: '"William R. Wilson"'
Autor:
Yongchuan Gu, Michael P. Hay, Muriel Bonnet, Robert F. Anderson, Kevin O. Hicks, William R. Wilson, Frederik B. Pruijn, Cho R. Hong, Jingli Wang
Publikováno v:
Bioorganicmedicinal chemistry. 22(7)
A novel class of nitroimidazole alkylsulfonamides have been prepared and evaluated as hypoxia-selective cytotoxins and radiosensitisers. The sulfonamide side chain markedly influences the physicochemical properties of the analogues: lowering aqueous
Autor:
Ralph J. Stevenson, Amir Ashoorzadeh, William R. Wilson, Graham J. Atwell, William A. Denny, Moana Tercel, Frederik B. Pruijn
Publikováno v:
Bioorganicmedicinal chemistry. 19(16)
A series of 3-substituted (5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl sulfonate (nitroCBI) prodrugs containing sulfonate leaving groups undergo hypoxia-selective metabolism to form potent DNA minor groove alkylating agents. They were evaluated
Autor:
Guo-Liang Lu, Ralph J. Stevenson, John Yu-Chih Chang, Penelope J. Brothers, David C. Ware, William R. Wilson, William A. Denny, Moana Tercel
Publikováno v:
Bioorganicmedicinal chemistry. 19(16)
A series of cobalt complexes of the potent DNA minor groove alkylator 1-(chloromethyl)-3-(5,6,7-trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinolin-5-ol (seco-6-azaCBI-TMI) were prepared from a series of N-substituted cyclen ligands.
Autor:
Graham J. Atwell, William A. Denny, Moana Tercel, Robert F. Anderson, Shangjin Yang, Yongchuan Gu, William R. Wilson, Frederik B. Pruijn, Eileen Smith
Publikováno v:
Bioorganicmedicinal chemistry. 18(14)
Nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-ones (nitroCBIs) are a new class of prodrugs for antitumor therapy that undergo hypoxia-selective metabolism to form potent DNA minor groove alkylating agents. Although hindered by poor aqueou