Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Hua Li"'
Autor:
Hong-Wei Jia, Hua-Li Yang, Zhi-Ling Xiong, Ming-Hui Deng, Tong Wang, Yang Liu, Maosheng Cheng
Publikováno v:
Bioorganic chemistry. 129
Inosine 5'-monophosphate dehydrogenase (IMPDH; EC1.1.1.205) is the rate-limiting enzyme of GMP biosynthesis. The inhibition of IMPDH limits the growth and survival of tumors. Based on the systematic summary of clinical IMPDH inhibitors, 38 acrylamide
Autor:
Zhaoming Liu, Weimin Zhang, Hao-Hua Li, Yuchan Chen, Haibo Tan, Zilei Huang, Jianlin Xu, Heng Guo, Saini Li, Xiaoxia Gao, Hongxin Liu
Publikováno v:
Bioorganic Chemistry. 87:728-735
Lithocarols A-F (1–6) possessing novel highly-oxygenated isobenzofuran core, together with a related known compound isoprenylisobenzofuran A (7) were isolated from the marine-derived fungus Phomopsis lithocarpus FS508. Among them, lithocarols A-E (
Autor:
Syed Nasir Abbas Bukhari, K.P. Rakesh, Hua-Li Qin, H.M. Manukumar, Moku Balakrishna, Xu Zhang
Publikováno v:
Bioorganic Chemistry. 80:86-93
The complications of Alzheimer's disease AD were deadly dangerous cause of neurodegenerative disorders connected with the decline of the cognitive functions and loss of memory. The common form of dementia is accounted as the sixth leading cause of th
Publikováno v:
Bioorganic chemistry. 110
Protein tyrosine phosphatase SHP2 is a member of PTPs family associated with cancer such as leukemia, non-small cell lung cancer, breast cancer, and so on. SHP2 is a promising target for drug development, and consequently it is of great significance
Autor:
Xuechen Zhou, Mengzhu Zheng, Na Zhao, Yixin Hu, Kaiyin Yang, Junfeng Huo, Guangyuan Liu, Jiangeng Huang, Lixia Chen, Yirong Zhou, Hua Li
Publikováno v:
Bioorganic Chemistry. 119:105569
Isocitrate dehydrogenases 1 (IDH1) catalyzes the oxidative decarboxylation of isocitrate to ɑ-ketoglutaric acid (α-KG). It is the most frequently mutated metabolic gene in human cancer and its mutations interfere with cell metabolism and epigenetic
Autor:
Wen-Wei You, Qiu Li, Jin-Jun Rao, Lin Chen, Xie-Er Jian, Zi-Hua Li, Pei-Liang Zhao, Xian-Sen Huo, Zhi-Ru Chen
Publikováno v:
Bioorganic chemistry. 102
A new series of derivatives characterized by the presence of the 3,4,5-trimethoxylbenzamide substituted benzofurans were synthesized and evaluated for antiproliferative activity against four cancer cell lines and one normal human cell line. Among the
Publikováno v:
Bioorganic chemistry. 97
The phytochemical investigation of Andrographis paniculata resulted in the isolation of a novel 15-spiro diterpenoid dimer bisandrographolide G (1). Its structure was determined by 1D and 2D NMR, HRESIMS, electronic circular dichroism (ECD), and TD D
Publikováno v:
Bioorganic Chemistry. 110:104809
Seven undescribed withanolides (1–7) and six artificial withanolides (8–13), along with 20 known compounds (14–33) were isolated from the aerial parts of Tubocapsicum anomalum. Their structures were confirmed by comprehensive spectroscopic anal
Publikováno v:
Bioorganic Chemistry. 72:130-147
The combretastatins are isolated from South African tree combretum caffrum kuntze. The lead compound combretastatin A-4 has displayed remarkable cytotoxic effect in a wide variety of preclinical tumor models and inhibits tubulin polymerization by int
Adapalene inhibits ovarian cancer ES-2 cells growth by targeting glutamic-oxaloacetic transaminase 1
Autor:
Qiqi Wang, Qingzhe Zhang, Shanshan Luan, Kaiyin Yang, Lixia Chen, Hua Li, Mengzhu Zheng, Kezhen Li
Publikováno v:
Bioorganic chemistry. 93
Glutamic-oxaloacetic transaminase 1 (GOT1) regulates cellular metabolism through coordinating the utilization of carbohydrates and amino acids to meet nutrient requirements for sustained proliferation. As such, the GOT1 inhibitor may provide a new st