Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Diabetes Mellitus"'
Autor:
Zahra Tayarani-Najaran, Razieh Ghodsi, Neda Shakour, Fatemeh Mosaffa, Gholamreza Karimi, Farzin Hadizadeh, Aida Tasbandi, Amirhossein Sahebkar, Maryam Paseban
Publikováno v:
Bioorganic chemistry. 115
A newly designed series of imidazolyl-methyl- l-2,4-thiazolidinediones 9 (a-m) were synthesized and In Silico studies were carried out to rationalize their anti-diabetic activity. Generally, all newly synthesized thiazolidinediones had anti-hyperglyc
Publikováno v:
Bioorganic chemistry. 113
Diabetes mellitus type 2 (T2D) is a group of genetically heterogeneous metabolic disorders whose frequency has gradually risen worldwide. Diabetes mellitus Type 2 (T2D) has started to achieve a pandemic level, and it is estimated that within the next
Publikováno v:
Bioorganic Chemistry. 86:305-315
Diabetes mellitus is a chronic metabolic disorder which is rapidly spreading worldwide. It is characterized by persistent elevated blood glucose level above normal values (hyperglycemia) due to defect in either insulin secretion or in insulin action
Autor:
Bin Chen, Wenjie Zhang, Wenlong Huang, Cai Xingguang, Cai Yan, Ting Han, Li Chengye, Hai Qian, Chunxia Liu, Yuxing Zou, Jiaxian Mo
Publikováno v:
Bioorganic chemistry. 106
Glucagon-like peptide-1 (GLP-1) receptor agonists as an effective approach for type 2 diabetes mellitus (T2DM) has been explored extensively, multi agonists based on GLP-1 may have better clinical benefits on obesity, Nonalcoholic steatohepatitis (NA
Publikováno v:
Bioorganic chemistry. 119
A novel ANAP (Aspergillus niger from alkaline protease) catalyzed one pot three component approach in the synthesis of new thiazolidinedione festooned quinoline analogues via Knoevenagel condensation and N-alkylation have been reported. The catalytic
Autor:
Sanaa A. Ali, Wahid M. Basyouni, Eman A Younis, Hanan F. Aly, Samir Y. Abbas, Khairy A. M. El-Bayouki
Publikováno v:
Bioorganic Chemistry. 117:105418
New sulfonylbiguanide hydrochloride salts and sulfonylurea derivatives containing two sulfonyl groups were synthesized through the reaction of arylsulfonohydrazides with cyanoguanidine and p-tolylsulfonylisocyanate, respectively. Oral treatment of hy
Autor:
Amelia Morrone, Paolo De Paoli, Francesca Cardona, Xhenti Ferhati, Andrea Goti, Camilla Matassini, Maria Giulia Fabbrini, Antonio J. Moreno-Vargas
Publikováno v:
Bioorganic Chemistry. 87:534-549
The diffusion of type 2 diabetes (T2D) throughout the world represents one of the most important health problems of this century. Patients suffering from this disease can currently be treated with numerous oral anti-hyperglycaemic drugs, but none is
Publikováno v:
Bioorganic Chemistry. 83:6-19
A series of new benzothiazole-1,3,4-oxadiazole-4-thiazolidinone hybrid analogs (Tz1-Tz28) were synthesized in search of potential anti-diabetic agents. Molecular docking study was conducted with binding pocket of peroxisome proliferator activated rec
Publikováno v:
Bioorganic Chemistry. 84:478-492
A new series of octadec-9-enoic acid schiff base entities (S1-S30) were designed and synthesized targeting peroxisome proliferator activated receptor-gamma for agonist action. Molinspiration software (online) was used to estimate drug like molecular
Autor:
Rui Gonçalves Marques Elias, Fátima Regina Mena Barreto Silva, Patrícia D. Neuenfeldt, Veronica Aiceles de Medeiros Pinto, Camila Pires Mendes, Cristiane da Fonte Ramos, Ricardo José Nunes, Marisa Jádna Silva Frederico, Bárbara Graziela Postal
Publikováno v:
Bioorganic chemistry. 114
A new library of hybrid compounds that combine the functional parts of glibenclamide and pioglitazone was designed and developed. Compounds were screened for their antihyperglycemic effects on the glucose tolerance curve. This approach provided a sin