Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Rehman, Abdul"'
Autor:
Jitendra A. Sattigeri, Ramesh B. Bambal, Takahide Nishi, Ajay Soni, Pragya Bhateja, Tarun Jain, Dilip J. Upadhyay, Nidhi Alekar, Tridib Chaira, Abdul Rehman Abdul Rauf, Mahesh Subhashrao Deshmukh, Malvika Garg, Tarani Kanta Barman, Mahendrakumar Gupta, Paras Kumar Jha
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2993-2997
FimH is a type I fimbrial lectin located at the tip of type-1 pili of Gram-negative uropathogenic Escherichia coli (UPEC) guiding its ability to adhere and infect urothelial cells. Accordingly, blocking FimH with small molecule inhibitor is considere
Autor:
Sattigeri, Jitendra A., Garg, Malvika, Bhateja, Pragya, Soni, Ajay, Rauf, Abdul Rehman Abdul, Gupta, Mahendrakumar, Deshmukh, Mahesh S., Jain, Tarun, Alekar, Nidhi, Barman, Tarani Kanta, Jha, Paras, Chaira, Tridib, Bambal, Ramesh B., Upadhyay, Dilip J., Nishi, Takahide
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 September 2018 28(17):2993-2997
Autor:
Keshav Naik, Viswajanani J. Sattigeri, Ajay Soni, Abhijit Ray, Rauf Abdul Rehman Abdul, Ian Anthony Cliffe, Vanya Shah, Sunanda G. Dastidar, Venkata P. Palle, Mohammad Sarwar Alam, Tridib Chaira
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1482-1485
A novel set of compounds containing a 4,5-dihydro-5-methylisoxazoline have been successfully designed as VLA-4 receptor antagonists. Compound (14p) had a high receptor binding affinity of 4 nM and also found to be metabolically stable in vitro.
Synthesis and biological activity of N-substituted aminocarbonyl-1,3-dioxolanes as VLA-4 antagonists
Autor:
Mohammad Sarwar Alam, Keshav Naik, Ajay Soni, Sreeji Nair, Mohammad Salman, Ian Anthony Cliffe, Abhijit Ray, Viswajanani J. Sattigeri, Rauf Abdul Rehman Abdul, Sunanda G. Dastidar, Venkata Palle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5514-5520
A novel set of compounds with a 1,3-dioxolane ring which acts as a proline bioisostere have been successfully designed as VLA-4 receptor antagonists. Compounds (18e), (28j), and (35g) were shown to have high receptor affinities.
Autor:
Soni, Ajay, Rehman, Abdul, Naik, Keshav, Dastidar, Sunanda, Alam, M.S., Ray, Abhijit, Chaira, Tridib, Shah, Vanya, Palle, Venkata P., Cliffe, Ian A., Sattigeri, Viswajanani J.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 March 2013 23(5):1482-1485
Synthesis and biological activity of N-substituted aminocarbonyl-1,3-dioxolanes as VLA-4 antagonists
Autor:
Rehman, Abdul, Soni, Ajay, Naik, Keshav, Nair, Sreeji, Palle, Venkata P., Dastidar, Sunanda, Ray, Abhijit, Alam, M.S., Salman, Mohammad, Cliffe, Ian A., Sattigeri, Viswajanani
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2010 20(18):5514-5520