Zobrazeno 1 - 10
of 58
pro vyhledávání: '"O'Hanlon, A."'
Elucidation of antimicrobial activity and mechanism of action by N-substituted carbazole derivatives
Autor:
Karen O'Hanlon Cohrt, Lasse Kjellerup, John Bondo Hansen, William Dalby-Brown, Anne-Marie Lund Winther, Johannes D. Clausen
Publikováno v:
Clausen, J D, Kjellerup, L, Cohrt, K OH, Hansen, J B, Dalby-Brown, W & Winther, A-M L 2017, ' Elucidation of antimicrobial activity and mechanism of action by N-substituted carbazole derivatives ', Bioorganic & Medicinal Chemistry Letters, vol. 27, no. 19, pp. 4564-4570 . https://doi.org/10.1016/j.bmcl.2017.08.067
Bioorganic & Medicinal Chemistry Letters
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
Compounds belonging to a carbazole series have been identified as potent fungal plasma membrane proton adenosine triphophatase (H+-ATPase) inhibitors with a broad spectrum of antifungal activity. The carbazole compounds inhibi
Compounds belonging to a carbazole series have been identified as potent fungal plasma membrane proton adenosine triphophatase (H+-ATPase) inhibitors with a broad spectrum of antifungal activity. The carbazole compounds inhibi
Elucidation of antimicrobial activity and mechanism of action by N-substituted carbazole derivatives
Autor:
Clausen, Johannes D., Kjellerup, Lasse, Cohrt, Karen O'Hanlon, Hansen, John Bondo, Dalby-Brown, William, Winther, Anne-Marie L.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 October 2017 27(19):4564-4570
Autor:
Jarvest, Richard L., Berge, John M., Houge-Frydrych, Catherine S.V., Janson, Cheryl, Mensah, Lucy M., O'Hanlon, Peter J., Pope, Andrew, Saldanha, Adrian, Xiayang Qiu
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1999 9(19):2859-2862
Autor:
Bennett, Isobel, Broom, Nigel J.P., Cassels, Robert, Elder, John S., Masson, Nicky D., O'Hanlon, Peter J.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1999 9(13):1847-1852
Autor:
Alison I. Muir, Shelagh Wilson, Christopher N. Johnson, Kim Winborn, Alex J. Stevens, Guillaume J. Hervieu, Peter J. O'Hanlon, Phillip Jeffrey, John H. Bateson, Kevin M. Thewlis, David R. Witty, Geoffrey Stemp
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4865-4871
We report here the discovery of a class of MCH R1 ligands based on a biphenyl carboxamide template. A docked-in model is presented indicating key interactions in the putative binding site of the receptor. Parallel high throughput synthetic techniques
Autor:
Sula Anne Armstrong, Pamela Brown, Darren Jason Mitchell, Stephen Rittenhouse, Dieter Hamprecht, Andrew Keith Forrest, Royston C. B. Copley, Peter J. O'Hanlon, John S. Elder, Richard L. Jarvest, Murray J. B. Brown, John M. Berge, David R. Witty
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:3937-3941
Potent inhibitors of bacterial methionyl tRNA synthetase (MRS) have previously been reported. Through SAR of the quinolone moiety, the right hand side pharmacophore for MRS inhibition has now been defined as an NH-C-NH functionality in the context of
Autor:
David R. Witty, Dieter Hamprecht, Ashley E. Fenwick, Paul S. Carter, Richard L. Jarvest, Murray J. B. Brown, Peter J. O'Hanlon, Martin Hibbs, Andrew J. Pope, Lucy Mensah, Christine M. Richardson, Peter Henry Milner, Andrew West, Andrew P. Fosberry
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:3171-3174
The antimicrobial natural product chuangxinmycin has been found to be a potent and selective inhibitor of bacterial tryptophanyl tRNA synthetase (WRS). A number of analogues have been synthesised. The interaction with WRS appears to be highly constra
Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase
Autor:
Pamela Brown, Peter J. O'Hanlon, Richard L. Jarvest, Lucy Mensah, Andrew J. Pope, Drake S. Eggleston, R. Curtis Haltiwanger
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:711-714
Novel inhibitors of bacterial tyrosyl tRNA synthetase have been synthesised in which the cyclic hydroxylamine moiety of SB-219383 is replaced by C-pyranosyl derivatives. Potent and selective inhibition of bacterial tyrosyl tRNA synthetase was obtaine
Autor:
Weimin Yue, Curtis F. Crasto, Tomislav Karoli, Lucy Mensah, Peter J. O'Hanlon, Martin G. Banwell, Andrew Keith Forrest, Christopher J. Easton, Darren R. March, Mark D Oldham, Michael R. Nairn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:2263-2266
SB-203207 and 10 analogues have been prepared, by elaboration of altemicidin, and evaluated as inhibitors of isoleucyl, leucyl and valyl tRNA synthetases (IRS, LRS, and VRS, respectively). Substituting the isoleucine residue of SB-203207 with leucine
Autor:
Nigel J. P. Broom, John Stephen Elder, Nicky D. Masson, Isobel Bennett, Robert Cassels, Peter J. O'Hanlon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1847-1852
A series of beta-diketone acrylate bioisosteres 4 of pseudomonic acid A 1 have been synthesized and evaluated for their ability to inhibit bacterial isoleucyl-tRNA synthetase and act as antibacterial agents. A number of analogues have excellent antib