Zobrazeno 1 - 2
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pro vyhledávání: '"Michelle Smith"'
Autor:
Margaret van Heek, Joe F. Lee, Michelle Smith, Mingxiang Lin, Nicolas Zorn, John R. Cook, Robert G. Aslanian, Pauline C. Ting, Scott S. Walker, Hyunjin M. Kim, Jean E. Lachowicz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:985-988
The structure-activity relationship studies of a novel series of carboxylic acid derivatives of pyridine-carboxamides as DGAT-1 inhibitors is described. The optimization of the initial lead compound 6 based on in vitro and in vivo activity led to the
Autor:
Haiqun Tang, Robert Mazzola, Duane A. Burnett, William J. Greenlee, Jean E. Lachowicz, Hongtao Zhang, Yuanzan Ye, Michelle Smith, Ahmad Fawzi, Zhaoning Zhu, Jing Su, Li Qiang, Mckittrick Brian A, T.K. Sasikumar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:836-840
A series of novel dopamine D(1) antagonists derived from functionalization of the D-ring of SCH 39166 were prepared. A number of these compounds displayed subnanomolar D(1) activity and more than 1000-fold selectivity over D(2). We found C-3 derivati