Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Gino In"'
Autor:
Brockunier, Linda, Stelmach, John, Guo, Jian, Spencer, Tracy, Rosauer, Keith, Bansal, Alka, Cai, Sheng-Jian, Chen, Nancy, Cummings, John, Huang, Li, Johnson, Timothy, Levesque, Sonia, Luo, Lin, Maloney, Kevin, Metzger, Joseph, Mortko, Christopher, Ortega, Karen, Pai, Lee-Yuh, Pereira, Antonio, Salituro, Gino, Shang, Jackie, Shepherd, Cherrie, Sherrie Xu, Shiyao, Yang, Qifeng, Cui, Jisong, Roy, Sophie, Parmee, Emma, Raghavan, Subharekha
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 November 2020 30(21)
Autor:
Joe Clemas, Jerry Andrew Taylor, Feroze Ujjainwalla, Jim Tata, Doris F. Cully, Tom Wisniewski, Wei Tang, Charlene Bopp, Clare London, Andreas Verras, Scott B. Hoyt, Andrea Sok, Elaine Tung, Douglas J. MacNeil, Gaochao Zhou, Amjad Ali, Qing Chen, Gino Salituro, Yusheng Xiong, Daniel R. McMasters, Mary Struthers, Ning Ren, Ruth A. Duffy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2384-2388
We report the discovery and hit-to-lead optimization of a structurally novel indazole series of CYP11B2 inhibitors. Benchmark compound 34 from this series displays potent inhibition of CYP11B2, high selectivity versus related steroidal and hepatic CY
Autor:
Hiroshi Nagabukuro, Sean M. Smith, Richard A. Berger, Melissa Costa, Nam Fung Kar, Bart Harper, Karen H. Dingley, Gino Salituro, Liping Wang, Jerry Di Salvo, Scott D. Edmondson, Bing Li, Xiaofang Li, Cheng Zhu, Christopher Moyes, Stephen D. Goble, Sookhee Ha, Mary Struthers, Jeffrey J. Hale, Amanda L. Hurley, Randy R. Miller
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:1094-1098
The synthesis of a novel class of piperazine benzamide (reverse amides) targeting the human β3-adrenergic receptor for the treatment of overactive bladder (OAB) is described. The SAR studies directed towards maintaining well established β3 potency
Autor:
Cherrie Shepherd, Sheng-Jian Cai, Subharekha Raghavan, Shiyao Sherrie Xu, Sonia Levesque, John E. Stelmach, Sophie Roy, Nancy Chen, Jackie Shang, Jisong Cui, Joseph M. Metzger, Gino Salituro, Alka Bansal, John Cummings, Keith G. Rosauer, Antonio Pereira, Kevin M. Maloney, Qifeng Yang, Linda Brockunier, Emma R. Parmee, Christopher J. Mortko, Li Huang, Timothy E. Johnson, Lee-Yuh Pai, Tracy Spencer, Karen Ortega, Jian Guo, Lin Luo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127574
The NO-sGC-cGMP signaling pathway plays an important role in the cardiovascular system. Loss of nitric oxide tone or impaired signaling has been associated with cardiovascular diseases, such as hypertension, pulmonary hypertension and heart failure.
Autor:
Cheng Zhu, Mary Struthers, Jerry Di Salvo, Bing Li, Jeffrey J. Hale, Ann E. Weber, Xiaofang Li, Randy R. Miller, Scott D. Edmondson, Melissa Costa, Nam Fung Kar, Sookhee Ha, Karen H. Dingley, Amanda L. Hurley, Gino Salituro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:55-59
The paper will describe the synthesis and SAR studies that led to the discovery of benzamide (reverse amide) as potent and selective human β3-adrenergic receptor agonist. Based on conformationally restricted pyrrolidine scaffold we discovered earlie
Autor:
Hoyt, Scott B., Taylor, Jerry, London, Clare, Ali, Amjad, Ujjainwalla, Feroze, Tata, Jim, Struthers, Mary, Cully, Doris, Wisniewski, Tom, Ren, Ning, Bopp, Charlene, Sok, Andrea, Verras, Andreas, McMasters, Daniel, Chen, Qing, Tung, Elaine, Tang, Wei, Salituro, Gino, Clemas, Joe, Zhou, Gaochao, MacNeil, Douglas, Duffy, Ruth, Xiong, Yusheng
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 June 2017 27(11):2384-2388
Autor:
Zhu, Cheng, Wang, Liping, Zhu, Yuping, Guo, Zack Zhiqiang, Liu, Ping, Hu, Zhiyong, Szewczyk, Jason W., Kang, Ling, Chicchi, Gary, Ehrhardt, Anka, Woods, Andrea, Seo, Toru, Woods, Morgan, van Heek, Margaret, Dingley, Karen H., Pang, Jianmei, Salituro, Gino M., Powell, Joyce, Terebetski, Jenna L., Hornak, Viktor, Campeau, Louis-Charles, Orr, Robert K., Ujjainwalla, Feroze, Miller, Michael, Stamford, Andrew, Wood, Harold B., Kowalski, Timothy, Nargund, Ravi P., Edmondson, Scott D.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 March 2017 27(5):1124-1128
Autor:
Harper, Bart H., Wang, Liping, Zhu, Cheng, Kar, Nam F., Li, Bing, Moyes, Christopher R., Goble, Stephen D., Costa, Melissa, Dingley, Karen, Di Salvo, Jerry, Ha, Sookhee N., Hurley, Amanda, Li, Xiaofang, Miller, Randy R., Nagabukuro, Hiroshi, Salituro, Gino M., Smith, Sean, Struthers, Mary, Hale, Jeffrey J., Edmondson, Scott D., Berger, Richard
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 February 2017 27(4):1094-1098
Autor:
Tesfaye Biftu, Xiaoxia Qian, Ping Chen, Dennis Feng, Giovanna Scapin, Ying-Duo Gao, Jason Cox, Ranabir Sinha Roy, George Eiermann, Huabing He, Kathy Lyons, Gino Salituro, Sangita Patel, Alexander Petrov, Feng Xu, Shiyao Sherrie Xu, Bei Zhang, Charles Caldwell, Joseph K. Wu, Ann E. Weber
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5361-5366
A series of novel tri-2,3,5-substituted tetrahydropyran analogs were synthesized and evaluated as inhibitors of dipeptidyl peptidase IV (DPP-4) for the treatment of type 2 diabetes. Optimization of the series provided inhibitors with good DPP-4 poten
Autor:
Zhu, Cheng, Kar, Nam F., Li, Bing, Costa, Melissa, Dingley, Karen H., Di Salvo, Jerry, Ha, Sookhee N., Hurley, Amanda L., Li, Xiaofang, Miller, Randy R., Salituro, Gino M., Struthers, Mary, Weber, Ann E., Hale, Jeffrey J., Edmondson, Scott D.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 January 2016 26(1):55-59