Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Gino In"'
Autor:
Cheng Zhu, Mary Struthers, Jerry Di Salvo, Bing Li, Jeffrey J. Hale, Ann E. Weber, Xiaofang Li, Randy R. Miller, Scott D. Edmondson, Melissa Costa, Nam Fung Kar, Sookhee Ha, Karen H. Dingley, Amanda L. Hurley, Gino Salituro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:55-59
The paper will describe the synthesis and SAR studies that led to the discovery of benzamide (reverse amide) as potent and selective human β3-adrenergic receptor agonist. Based on conformationally restricted pyrrolidine scaffold we discovered earlie
Autor:
Richard G. Ball, Sheila M. Galloway, Katherine K. McGettigan, Harvey R. Wendt, Gregori J. Morriello, Jerry Di Salvo, Marat Vijay Reddy, Black Regina M, Amanda L. Hurley, Judy Morris, Scott D. Feighner, Eric Streckfuss, George A. Doss, Alka Bansal, Anthony Sanfiz, Scott D. Edmondson, Mary Struthers, Nancy N. Tsou, Jiafang He, Crystal McKnight, George M. Laws, Donna L. Hreniuk, Gino Salituro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1865-1870
A novel class of human β(3)-adrenergic receptor agonists was designed in effort to improve selectivity and metabolic stability versus previous disclosed β(3)-AR agonists. As observed, many of the β(3)-AR agonists seem to need the acyclic ethanolam
Autor:
Aleksandr Petrov, Lihu Yang, Ralph T. Mosley, Carina P. Tan, George J. Eiermann, Joel P. Berger, Sanjeev Kumar, Peter T. Meinke, Eric Chang, Sander G. Mills, Nancy A. Thornberry, Cheng Tang, Monica Einstein, Eric Cline, Yun-Ping Zhou, Min Ge, Songnian Lin, Andrew D. Howard, Yue Feng, Changyou Zhou, Taro E. Akiyama, Gino Salituro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1298-1301
Systematic structure-activity relationship (SAR) studies of a screening lead led to the discovery of a series of thiazolidinediones (TZDs) as potent GPR40 agonists. Among them, compound C demonstrated an acute mechanism-based glucose-lowering in an i
Autor:
Simone Bertini, Chiara Papi, Filippo Minutolo, Silvia Barontini, Giorgio Placanica, Marco Macchia, Laura Betti, Romano Danesi, Gino Giannaccini, Gianbattista Gervasi, Simona Rapposelli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4405-4408
Phosphonoacetamido(oxy) groups have proven to be good mimics of the diphosphate portion in geranylgeranyl protein transferase I (GGTase I) inhibitors. The introduction of small alkyl groups (Me, Et) into the diphosphate mimic moiety caused a further