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Autor:
Clyde G. McNamee, Bang-Chi Chen, Ronald L. Hanson, Gus A. Kodersha, Amit Banerjee, Mark D. Schwinden, Ramesh N. Patel, David R. Kronenthal, David B. Brzozowski, Bharat P. Patel, Laszlo J. Szarka
Publikováno v:
Bioorganic & Medicinal Chemistry. 7:2247-2252
L-6-Hydroxynorleucine, a key chiral intermediate used for synthesis of a vasopeptidase inhibitor, was prepared in 89% yield and > 99% optical purity by reductive amination of 2-keto-6-hydroxyhexanoic acid using glutamate dehydrogenase from beef liver