Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Hiroyuki Miyachi"'
Autor:
Takuji Oyama, Ken Kataoka, Masao Ohashi, Nam Ho Huh, Masakazu Yashiro, Hiromi Nobusada, Kenji Matsuno, Hiroyuki Miyachi, Tsuyoshi Waku, Kosuke Morikawa, Endy Widya Putranto
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:2319-2332
In the continuing study directed toward the development of peroxisome proliferator-activated receptor gamma (hPPARγ) agonist, we attempted to improve the water solubility of our previously developed hPPARγ-selective agonist 3, which is insufficient
Autor:
Makoto Makishima, Hiromi Nobusada, Izumi Nakagome, Shuichi Hirono, Yuichi Hashimoto, Kenji Matsuno, Jun Ichi Kasuga, Hiroyuki Miyachi, Masao Ohashi
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:6375-6383
We previously demonstrated that the α-benzylphenylpropanoic acid-type PPARγ-selective agonist 6 exhibited a reversed stereochemistry-activity relationship, that is, the (R)-enantiomer is a more potent PPARγ agonist than the (S)-enantiomer, compare
Autor:
Mohammed T.A. Salim, Hiroshi Aoyama, Yuichi Hashimoto, Mika Okamoto, Masanori Baba, Masahiko Nakamura, Hiroyuki Miyachi, Atsushi Aoyama
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:2402-2411
A phenanthridinone skeleton was derived from our previous researches on thalidomide and retinoids as a multi-template for generation of anti-viral lead compounds. Structural development studies focusing on anti-hepatitis C virus activity afforded 5-b
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:6799-6812
Various 4-(anilino)pyrrole-2-carboxamides were designed and synthesized as novel androgen receptor (AR) antagonists without steroidal or anilide structure, based on our strategy for developing full antagonists of nuclear receptors. Introduction of a
Autor:
Satoko Maeda, Minoru Yoshida, Chihiro Shinji, Yuichi Hashimoto, Keisuke Imai, Hiroyuki Miyachi
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:7625-7651
A series of hydroxamic acid derivatives bearing a cyclic amide/imide group as a linker and/or cap structure, prepared during our structural development studies based on thalidomide, showed class-selective potent histone deacetylase (HDAC)-inhibitory
Autor:
Kazuo Nagasawa, Shinnosuke Hosoda, Yuichi Hashimoto, Makoto Makishima, Ken-ichi Wakabayashi, Keisuke Imai, Hiroyuki Miyachi, Aya Tanatani
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:5489-5502
Ligands possessing dual vitamin D 3 (VD 3 )-agonistic and androgen–antagonistic activities with various activity spectra were prepared based on a substituted 3,3-diphenylpentane (DPP) skeleton. Among the compounds, ( R , S )-DPP-1023 [( R , S )- 7b
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:2837-2846
We designed and synthesized novel pyrrole-2-carboxamide derivatives as androgen antagonists. Compounds 10 and 13 bearing benzylamine or aniline at the 4-position of the pyrrole ring showed moderate androgen antagonistic activity, and inhibited the an
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:2095-2102
N -Substituted phthalimides (2-substituted 1 H -isoindole-1,3-diones) were prepared and their inhibitory effects on tumor necrosis factor-alpha (TNF-α) production by human leukemia cell line THP-1 stimulated with 12- O -tetradecanoylphorbol 13-aceta