Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Hiroshi Sugiyama"'
Publikováno v:
Bioorganic & Medicinal Chemistry. 81:117208
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:2167-2171
Hairpin pyrrole–imidazole (Py-Im) polyamides are promising medium-sized molecules that bind sequence-specifically to the minor groove of B-form DNA. Here, we synthesized a series of hairpin Py-Im polyamides and explored their binding affinities and
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:278-284
Electron transfer through π-stacked arrays of double-stranded DNA contributes to the redox chemistry of bases, including guanine oxidation and thymine–thymine dimer repair by photolyase. 5-Bromouracil is an attractive photoreactive thymine analogu
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:1393-1411
Pyrrole–imidazole polyamides (Py–Im polyamides) are cell-permeable compounds that bind to the minor groove of double-stranded DNA in a sequence-specific manner without causing denaturation of the DNA. These compounds can be used to control gene e
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:37-40
Given that our knowledge of DNA repair is limited because of the complexity of the DNA system, a technique called UVA micro-irradiation has been developed that can be used to visualize the recruitment of DNA repair proteins at double-strand break (DS
Autor:
Gengo Kashiwazaki, Yoshito Sawatani, Toshikazu Bando, Anandhakumar Chandran, Kaori Hashiya, Chuanxin Guo, Shinsuke Sato, Sefan Asamitsu, Hiroshi Sugiyama
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:3603-3611
With the aim of improving aqueous solubility, we designed and synthesized five N-methylpyrrole (Py)–N-methylimidazole (Im) polyamides capable of recognizing 9-bp sequences. Their DNA-binding affinities and sequence specificities were evaluated by S
Autor:
Toshikazu Bando, Kaori Hashiya, Makoto Yamamoto, Fumitaka Hashiya, Sefan Asamitsu, Hiroshi Sugiyama, Seiichiro Kizaki, Yusuke Kawamoto
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:4646-4657
Introducing novel building blocks to solid-phase peptide synthesis, we readily synthesized long-chain hairpin pyrrole-imidazole (PI) polyamide-chlorambucil conjugates 3 and 4 via the introduction of an amino group into a GABA (γ-turn) contained in 3
Autor:
Gengo, Kashiwazaki, Rina, Maeda, Takashi, Kawase, Kaori, Hashiya, Toshikazu, Bando, Hiroshi, Sugiyama
Publikováno v:
Bioorganic & Medicinal Chemistry.
Autor:
Tomohiro Takenaka, Hironobu Morinaga, Hiroshi Sugiyama, Yuta Sannohe, Ryu Tashiro, Seiichiro Kizaki, Shuhei Kanesato
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:466-469
5-Bromouracil ( Br U) was incorporated into three types of synthetic RNA and the products of the photoirradiated Br U-containing RNAs were investigated using HPLC and MS analysis. The photoirradiation of r(GCA Br UGC) 2 and r(CGAA Br UUGC)/r(GCAAUUCG
Autor:
Yuta Sannohe, Hiroshi Sugiyama
Publikováno v:
Bioorganic & medicinal chemistry. 20(6):2030-2034
DNA is a good material for constructing nanostructures such as DNA origami. One of the challenges in this field is constructing a topologically complex structure. Here, we synthesized a DNA catenane through the formation of a G-quadruplex structure.