Zobrazeno 1 - 10
of 4 065
pro vyhledávání: '"0301 basic medicine"'
Autor:
Matheus Mulling dos Santos, Luana Caroline Schüler, Gabriel Teixeira de Macedo, João Luís Souza Vargas, Nilda de Vargas Barbosa, Andreza Fabro de Bem, Sabrina Antunes Ferreira, Alessandro de Souza Prestes
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 142, Iss, Pp 111196-(2021)
Oxidized LDL (oxLDL) plays a pivotal role on atherosclerosis development, mainly in the formation of lipid-laden macrophage "foam cells". As a consequence, substances that can modulate LDL oxidation have a pharmacological and therapeutic relevance. B
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 142, Iss, Pp 111666-(2021)
Diabetic nephropathy (DN) is a diabetic complication characterized by disruption of renal microvasculature, reactive oxygen species accumulation and increased inflammation, all of which contribute to renal injury. Phenethyl isothiocyanate (PEITC) is
Autor:
Zhi-Ping Jiang, Wei Zhang, Fang Yuan, Gan Zhou, Cao Shan, Cong Cheng, Xie-Lan Zhao, Hong-Hao Zhou, Xiao-Ping Chen
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 142, Iss, Pp 111652-(2021)
Chemotherapy resistance remains to be the primary barrier to acute myeloid leukemia (AML) treatment failure. Nuclear factor-erythroid 2-related factor 2 (Nrf2) has been well established as a truly pleiotropic transcription factor. Inhibition of Nrf2
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss, Pp 111839-(2021)
If mitochondrial energy availability or oxidative metabolism is altered, patients will suffer from insufficient energy supply Phosphocreatine (PCr) not only acts as an energy carrier, but also acts as an antioxidant and defensive agent to maintain th
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss, Pp 111850-(2021)
Gut microbiome is considered as a crucial regulator of human health. Alteration of gut microbiome has been reported in acute pancreatitis (AP) and probably contributes to the severity of disease. Explore the precise role of gut microbiome in the path
Autor:
Lingbin Meng, Lihua Dong, Zhuangzhuang Zheng, Qin Zhao, Xin Jiang, Weiyan Shi, Zijing Liu, Shiyu Liu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss, Pp 111810-(2021)
Glioblastoma (GBM) is a challenging cancer with poor prognosis. The classical standard for treatment is safe resection, followed by concurrent chemoradiotherapy with subsequent adjuvant temozolomide (TMZ). Despite several attempts at different treatm
Autor:
Seidamir Pasha Tabaeian, Abolfazl Akbari, Ana Beatriz Pizarro, Zahra Rostami, Javad Heshmati, Meghdad Sedaghat, Sadegh Dehghani, Shahram Agah
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss, Pp 111849-(2021)
Curcumin is a bioactive ingredient found in the Rhizomes of Curcuma longa. Curcumin is well known for its chemopreventive and anti-cancer properties. Recent findings have demonstrated several pharmacological and biological impacts of curcumin, relate
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss, Pp 111606-(2021)
Introduction The development of multidrug resistance (MDR) is a major cause for the failure of chemotherapy, which requires the aid of nanomedicine. Methods Here in our study, a Cu2+ based metal-organic framework (COF) was firstly developed and emplo
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss, Pp 111822-(2021)
Cancer-induced bone pain (CIBP) is a refractory form of pain that has a high incidence in advanced tumors. Src protein tyrosine kinase is mainly composed of six domains, with two states of automatic inhibition and activation. The modular domain allow
Autor:
Ghali E.N. Hanuma Kumar, Muppuru Kesavulu, Sandopu Sravan Kumar, Meriga Balaji, Dharmendra Kumar Maurya
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss, Pp 111801-(2021)
Plant-based natural extracts contain several nutrients and bioactive compounds, such as phenolics and flavonoids, that possess various health-promoting activities. This study investigated the effects of polyphenols from Pterocarpus santalinus hydroal