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Autor:
Matheus Mulling dos Santos, Luana Caroline Schüler, Gabriel Teixeira de Macedo, João Luís Souza Vargas, Nilda de Vargas Barbosa, Andreza Fabro de Bem, Sabrina Antunes Ferreira, Alessandro de Souza Prestes
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 142, Iss, Pp 111196-(2021)
Oxidized LDL (oxLDL) plays a pivotal role on atherosclerosis development, mainly in the formation of lipid-laden macrophage "foam cells". As a consequence, substances that can modulate LDL oxidation have a pharmacological and therapeutic relevance. B
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 142, Iss, Pp 111666-(2021)
Diabetic nephropathy (DN) is a diabetic complication characterized by disruption of renal microvasculature, reactive oxygen species accumulation and increased inflammation, all of which contribute to renal injury. Phenethyl isothiocyanate (PEITC) is
Autor:
Zhi-Ping Jiang, Wei Zhang, Fang Yuan, Gan Zhou, Cao Shan, Cong Cheng, Xie-Lan Zhao, Hong-Hao Zhou, Xiao-Ping Chen
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 142, Iss, Pp 111652-(2021)
Chemotherapy resistance remains to be the primary barrier to acute myeloid leukemia (AML) treatment failure. Nuclear factor-erythroid 2-related factor 2 (Nrf2) has been well established as a truly pleiotropic transcription factor. Inhibition of Nrf2
Autor:
Seidamir Pasha Tabaeian, Abolfazl Akbari, Ana Beatriz Pizarro, Zahra Rostami, Javad Heshmati, Meghdad Sedaghat, Sadegh Dehghani, Shahram Agah
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss, Pp 111849-(2021)
Curcumin is a bioactive ingredient found in the Rhizomes of Curcuma longa. Curcumin is well known for its chemopreventive and anti-cancer properties. Recent findings have demonstrated several pharmacological and biological impacts of curcumin, relate
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss, Pp 111606-(2021)
Introduction The development of multidrug resistance (MDR) is a major cause for the failure of chemotherapy, which requires the aid of nanomedicine. Methods Here in our study, a Cu2+ based metal-organic framework (COF) was firstly developed and emplo
Autor:
Ghali E.N. Hanuma Kumar, Muppuru Kesavulu, Sandopu Sravan Kumar, Meriga Balaji, Dharmendra Kumar Maurya
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss, Pp 111801-(2021)
Plant-based natural extracts contain several nutrients and bioactive compounds, such as phenolics and flavonoids, that possess various health-promoting activities. This study investigated the effects of polyphenols from Pterocarpus santalinus hydroal
Autor:
Milad Ashrafizadeh, Amir Reza Aref, Farid Hashemi, Seyed Omid Sharifzadeh, Leyla Soleymani, Hossein Saleki, Sepideh Mirzaei, Saeed Samarghandian, Haroon Khan, Amirhossein Zabolian, Ali Zarrabi, Alan Prem Kumar, Kiavash Hushmandi, Salman Daneshi
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss, Pp 111824-(2021)
Epithelial-to-mesenchymal transition (EMT) mechanism is responsible for metastasis and migration of cancer cells to neighboring cells and tissues. Morphologically, epithelial cells are transformed to mesenchymal cells, and at molecular level, E-cadhe
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss, Pp 111836-(2021)
Purpose To investigate the therapeutic effects of vitamin A (VitA) or vitamin D (VitD) against bronchopulmonary dysplasia (BPD) and the underlying mechanism from the perspective of macrophage polarization. Methods A BPD model was established on rats.
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss, Pp 111808-(2021)
Galangin, a non-toxic phytochemical is known to possess several therapeutic applications. Mounting evidences have demonstrated that galangin a naturally available flavonoid exerts anticancer effects via several mechanisms. The phytocompound induces a
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 140, Iss, Pp 111797-(2021)
Sodium Thiosulfate (STS) is already reported as an antioxidant, anti-inflammatory agent with antiseptic, antifungal properties. The search for an ideal antiseptic still continues, which is lethal to all types of bacteria and their spores and sustain