Zobrazeno 1 - 10
of 216
pro vyhledávání: ''
Autor:
Katherine Nguyen, Shu Chien, Satenick Thorossian, Ricardo Serrano, Yi Shuan Julie Li, Juan C. del Álamo, Yi-Ting Yeh, Clarissa Hoffman, Kuei Chun Wang, Josh Wei
Publikováno v:
Biomaterials
The use of biochemical signaling to derive smooth muscle cells (SMCs) from mesenchymal stem cells (MSCs) has been explored, but the induction of a fully functional SMC phenotype remains to be a major challenge. Cell morphology has been shown to regul
Autor:
Tong Mook Kang, Jong-Sun Kang, Debojyoti De, Varun Bansal, Jieun An, Hyeon-Ju Jeong, Kyeong Kyu Kim
Publikováno v:
Biomaterials. 193:30-46
Use of stem cells in regenerative medicine holds great promise in treating people suffering from various otherwise incurable ailments. Direct conversion of somatic cells to other lineages thereby bypassing the intermediate pluripotent state has enorm
Autor:
Young Woo Park, Jaesung Park, Yu Suk Choi, Dong Yun Lee, Hayeon Byun, Luke G. Major, Heungsoo Shin, Se jeong Kim
Publikováno v:
Biomaterials. 188:198-212
Stem cell spheroids have been studied extensively in organoid culture and therapeutic transplantation. Herein, hydrogels with an embossed surface (HES) were developed as an all-in-one platform that can enable the rapid formation and culture of a larg
Publikováno v:
Biomaterials. 178:109-121
Ischemic diseases, such as peripheral artery disease, affect millions of people worldwide. While CD4+ T-cells regulate angiogenesis and myogenesis, it is not understood how the phenotype of these adaptive immune cells regulate these regenerative proc
Autor:
Zi Yin, Yangwu Chen, Weiliang Shen, Yanjie Zhang, Jiayun Huang, Bo Zhou, Richun Liu, Chunmei Fan, Jie Han, Peishan Wu, Hongwei Ouyang, Wei Ju, Chenqi Tang, Yanyan Zhao, Hong Zhang, Xiao Chen, Shichen Zhang, Xiaoyi Chen
Publikováno v:
Biomaterials. 280:121238
Three dimensional (3D) microenvironments more accurately replicate native microenvironments for stem cell maintenance and function compared with two dimensional (2D) microenvironments. However, the molecular mechanisms by which 3D microenvironments r
Autor:
Venktesh S. Shirure, Daniel C. Link, Drew Elizabeth Glaser, Natalie R. Ng, Leif S. Anderson, Matthew B. Curtis, Peter A. Sariano, Zachary A. Rollins, Aravind Anand, Steven C. George, Alyssa M. Deely, Jeremy M. Lowen, Bhupinder S. Shergill, Katherine N. Weilbaecher
Publikováno v:
Biomaterials. 280:121245
Animal models of bone marrow have limited spatial and temporal resolution to observe biological events (intravasation and cellular egress) and are inadequate to dissect dynamic events at the niche level (100 microns). Utilizing microfluidic and stem
Publikováno v:
Biomaterials. 175:19-29
Under the severe trauma condition, the skeletal muscles regeneration process is inhibited by forming fibrous scar tissues. Understanding the interaction between bioactive nanomaterials and myoblasts perhaps has important effect on the enhanced skelet
Autor:
Xiao Han, Zuyuan Luo, Jijia Pan, Yi Sui, Rui Shi, Yan Li, Siqi Zhang, Yalin Lyu, Shicheng Wei, Yuanyuan Zhang, Hao Liu, Zhixiu Xu, En Luo, Yue Yang
Publikováno v:
Biomaterials. 163:25-42
The efficacy of stem cell-based bone tissue engineering has been hampered by cell death and limited fate control. A smart cell culture system with the capability of sequentially delivering multiple factors in specific growth stages, like the mechanis
Autor:
Sajeesh Kumar Madhurakkat Perikamana, Hayeon Byun, Taufiq Ahmad, Jinkyu Lee, Sangmin Lee, Heungsoo Shin, Eun Mi Kim
Publikováno v:
Biomaterials. 165:79-93
Tendon-bone interface tissue is extremely challenging to engineer because it exhibits complex gradients of structure, composition, biologics, and cellular phenotypes. As a step toward engineering these transitional zones, we initially analyzed how di
Autor:
Young-Ae Choi, Nak Jeong Kim, Tae-Geon Kwon, Hong-In Shin, So-Young Choi, Eui Kyun Park, Young Kyung Kim, Hui-suk Yun, Myung Ae Bae, Yong Chul Bae, Tae-Yub Kwon, Jung-Eun Kim, Ju Ang Kim
Publikováno v:
Biomaterials. 157:51-61
Incorporating bioactive molecules into synthetic ceramic scaffolds is challenging. In this study, to enhance bone regeneration, a magnesium phosphate (MgP) ceramic scaffold was incorporated with a novel indene compound, KR-34893. KR-34893 induced the