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Autor:
Robin Zinke, Barbara Klajnert-Maculewicz, Łukasz Pułaski, Maciej Studzian, Michał Gorzkiewicz, Izabela Jatczak-Pawlik, Dietmar Appelhans
Publikováno v:
Biomacromolecules
New therapeutic strategies for personalized medicine need to involve innovative pharmaceutical tools, for example, modular nanoparticles designed for direct immunomodulatory properties. We synthesized mannose-functionalized poly(propyleneimine) glyco
Autor:
Pouya Faridi, Thomas P. Davis, Yanting Xing, Ava Faridi, Feng Ding, Anthony W. Purcell, Emily H. Pilkington, Ibrahim Javed, Aleksandr Kakinen, Aparna Nandakumar, Pu Chun Ke, Kairi Koppel, Ritchlynn Aranha
Publikováno v:
Biomacromolecules
Alzheimer’s disease (AD) is the most severe form of neurological disorder, characterized by the presence of extracellular amyloid-β (Aβ) plaques and intracellular tau tangles. For decades, therapeutic strategies against the pathological symptoms
Autor:
Akihiro Nishiguchi, Tetsushi Taguchi
Publikováno v:
Biomacromolecules. 20:1385-1393
An injectable bone may serve as a minimally invasive therapy for large orthopedic defects and osteoporosis and an alternative to allografting and surgical treatment. However, conventional bone substitutes lack the desirable biodegradability, biorespo
Publikováno v:
Biomacromolecules
A pressing need exists for antigen-specific immunotherapies (ASIT) that induce selective tolerance in autoimmune disease while avoiding deleterious global immunosuppression. Multivalent soluble antigen arrays (SAgA(PLP:LABL)), consisting of a hyaluro
Autor:
Francisco J. Martinez-Becerra, Jun Chen, Michelle Sarnowski, Cory Berkland, David S. Moore, Brittany L. Hartwell, Heather E. Shinogle
Publikováno v:
Biomacromolecules. 17:710-722
A pressing need exists for autoimmune disease therapies that act in an antigen-specific manner while avoiding global immunosuppression. Multivalent soluble antigen arrays (SAgAPLP:LABL), designed to induce tolerance to a specific multiple sclerosis a
Autor:
Madhavi P. Kadakia, Lawrence F. Drummy, Mary K. Leonard, Athanasios Bubulya, Christopher A. Vaiana, Richard A. Vaia, Rajesh R. Naik, Kristi M. Singh
Publikováno v:
Biomacromolecules. 12:3139-3146
Wound healing is a complex, multistep process that can be summarized into three stages, namely, hemostasis and inflammation, proliferation, and finally, tissue remodeling. Battlefield wound healing demands rapid hemostasis using clotting or cauterizi
Autor:
Shih Tak Khew, Yen Wah Tong
Publikováno v:
Biomacromolecules. 8:3153-3161
In this study, the affinity of two different cell types toward a specific cell binding sequence (Gly-Phe-Hyp-Gly-Glu-Arg or GFOGER) derived from type I collagen using peptide template (PT)-assembled collagen peptides of different triple helicity as a