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of 17
pro vyhledávání: '"35"'
Autor:
Shan Xie, J. John Mann, Victoria Arango, Thomas B. Cooper, Suham Kassir, Basalingappa L. Hungund, K. Yaragudri Vinod
Publikováno v:
Biological Psychiatry. 57:480-486
Background: Alcoholism is often comorbid with mood disorders and suicide. We recently reported an upregulation of CB1 receptor-mediated signaling in the dorsolateral prefrontal cortex (DLPFC) of subjects with major depression who died by suicide. In
Publikováno v:
Biological Psychiatry. 40:89-97
We measured adrenal gland volume and both baseline and stimulated pituitary and adrenal cortical hormones in 35 unmedicated, major depressives and 35 individually matched normal control subjects. Mean adrenal volume in the depressives was significant
Autor:
Andrew S. Fox, Steven E. Shelton, Heather C. Abercrombie, Ned H. Kalin, Terrence R. Oakes, Richard J. Davidson, Allison L. Jahn
Publikováno v:
Biological Psychiatry. 67:175-181
Background Hypothalamic-pituitary-adrenal (HPA) system activation is adaptive in response to stress, and HPA dysregulation occurs in stress-related psychopathology. It is important to understand the mechanisms that modulate HPA output, yet few studie
Autor:
Michael Kellner, Kirsten Riedesel, Klaus Wiedemann, Steffen Moritz, Johannes Botzenhardt, Kim Hinkelmann, Christian Otte
Publikováno v:
Biological Psychiatry. 66:879-885
Background Cognitive deficits and elevated cortisol are hallmarks of depression. Cortisol acts via mineralocorticoid and glucocorticoid receptors, which have their highest density in the hippocampus, a brain area closely related to cognitive function
Publikováno v:
Biological Psychiatry. 59:689-695
Background Individuals with mood disorders exhibit altered function of the hypothalamic-pituitary-adrenal (HPA) axis in response to stress. The glucocorticoid receptor (GR) plays an important role in the negative feedback regulation of the HPA axis.
Autor:
Anderson Mon, Dieter J. Meyerhoff, Christoph Abé, Timothy C. Durazzo, Stefan Gazdzinski, Donna E. Murray
Publikováno v:
Durazzo, Timothy C; Meyerhoff, Dieter J; Mon, Anderson; Abé, Christoph; Gazdzinski, Stefan; & Murray, Donna E. (2016). Chronic Cigarette Smoking in Healthy Middle-Aged Individuals Is Associated With Decreased Regional Brain N-acetylaspartate and Glutamate Levels.. Biological psychiatry, 79(6), 481-488. doi: 10.1016/j.biopsych.2015.03.029. UCSF: Retrieved from: http://www.escholarship.org/uc/item/1sj3t99t
Biological psychiatry, vol 79, iss 6
Biological psychiatry, vol 79, iss 6
BACKGROUND: Cigarette smoking is associated with metabolite abnormalities in anterior brain regions, but it is unclear if these abnormalities are apparent in other regions. Additionally, relationships between regional brain metabolite levels and meas
Autor:
Jean-Michel Aubry, Nicola Gervasoni, Gilles Bertschy, Michèle Schwald, Guido Bondolfi, Félicien Karege
Publikováno v:
Biological Psychiatry. 57:1068-1072
Background Recent reports have suggested a role for brain-derived neurotrophic factor (BDNF) in psychiatric disorders. Decreased serum BDNF levels have been reported in major depression, but the cause of this decrease has not yet been investigated. T
Publikováno v:
Biological Psychiatry. 48:989-995
Background: The authors sought to examine whether levels of dehydroepiandrosterone are abnormal in depression. Methods: Three groups of subjects aged 20–64 were studied: 44 major depressives, 35 subjects with partially or completely remitted depres
Autor:
Jessica L Kissler, Brendan M. Walker, Daniel J. Reis, Heiko T. Jansen, Sunil Sirohi, Daniel G. Smith, Raymond M. Quock
Publikováno v:
Biological psychiatry. 75(10)
Background The dynorphin (DYN)/kappa-opioid receptor (KOR) system undergoes neuroadaptations following chronic alcohol exposure that promote excessive operant self-administration and negative affective-like states; however, the exact mechanisms are u
Publikováno v:
Biological Psychiatry. 37:442-447
Dysfunction of brain serotonergic symptoms may be a factor in the mood and behavioral disturbances associated with depression. Platelet serotonin measures represent indirect but easily obtainable indices of brain serotonin function. To examine the sp