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Publikováno v:
Biological Psychiatry. 61:78-86
Background Alcohol dependence is characterized by excessive alcohol consumption, loss of control over intake, and the presence of a withdrawal syndrome, which includes both motivational and physical symptoms. Similar to human alcoholics, ethanol-depe
Publikováno v:
Biological psychiatry. 40(7)
Carbamazepine ( CBZ ) resembles lithium in its beneficial effects in therapy and prophylaxis of affective disorders. Since lithium is presumed to act via an attenuation of the inositolphos-phate/Ca 2+ -second messenger system, it is of particular int
Publikováno v:
Biological psychiatry. 30(2)
Excitatory amino acids, acting at the N-methyl-d-aspartate (NMDA) receptor, have been postulated to play an important role in the acquisition of behavior (learning). Previous studies have shown that some forms of response acquisition can be impaired
Autor:
Ronald F. Mucha
Publikováno v:
Biological psychiatry. 27(5)
Is oral naltrexone, a favored mode of therapy, aversive? Does a negative motivational effect of an antagonist occur whenever there is blockade of opioid receptors? The present two experiments investigated these questions
Publikováno v:
Biological Psychiatry. 21:1114-1122
Chronic administration of the neuroleptic haloperidol, the calcium channel antagonist nitrendipine, and the calcium channel antagonist neuroleptic pimozide produce differential effects on rat striatal 3H-spiperone binding. Following 7 days of 10 mg/k
Publikováno v:
Biological psychiatry. 20(6)
To test the hypothesis that a new potent and selective 5-HT2 receptor antagonist would be an excellent blocker of D,L-5-hydroxytryptophan (5-HTP)-induced response suppression in an animal model of depression, we administered LY53857 60 min prior to 5