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Publikováno v:
Neuropharmacology
Ketamine, an NMDA receptor antagonist and fast acting antidepressant, produces a rapid burst of glutamate in the ventral medial prefrontal cortex (mPFC). Preclinical studies have demonstrated that pyramidal cell activity in the vmPFC is necessary for
Autor:
Deepak Cyril D'Souza, Patrick D. Skosnik, Brian Pittman, Mohini Ranganathan, Bruce M. Cohen, R. Andrew Sewell, Ashley Schnakenberg
Publikováno v:
Biological Psychiatry. 72:871-879
Background Salvia divinorum (Salvia) is an increasingly popular recreational drug amongst adolescents and young adults. Its primary active ingredient, Salvinorin A (SA)—a highly selective agonist at the κ opiate receptor—is believed to be one of
Autor:
Zuzana Justinova, Walter Fratta, Leigh V. Panlilio, Godfrey H. Redhi, Sevil Yasar, Antonio Luchicchi, Chanel Barnes, Paola Mascia, Gianluigi Tanda, Daniele Piomelli, Salvatore Lecca, Bernard Le Foll, Steven R. Goldberg, Paola Fadda, Marco Pistis, Maria Scherma
Publikováno v:
Mascia, P; Pistis, M; Justinova, Z; Panlilio, LV; Luchicchi, A; Lecca, S; et al.(2011). Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. Biological Psychiatry, 69(7), 633-641. doi: 10.1016/j.biopsych.2010.07.009. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/4df5w07p
Background Recent findings indicate that inhibitors of fatty acid amide hydrolase (FAAH) counteract the rewarding effects of nicotine in rats. Inhibition of FAAH increases levels of several endogenous substances in the brain, including the endocannab
Publikováno v:
Biological Psychiatry. 67:804-811
Background Growing evidence supports a role of metabotropic glutamate receptors (mGluRs) in ethanol reinforcement, ethanol seeking, and ethanol withdrawal. To extend the understanding of the role of mGluRs in the addiction-relevant effects of ethanol
Autor:
Jin Kim, Il-Seon Shin, Jong-Keun Kim, Jae-Min Kim, Kyung-Yeol Bae, Sung-Wan Kim, Hee-Young Shin, Jin-Sang Yoon, Tak Youn
Publikováno v:
Biological Psychiatry. 67:840-845
Background Acetaldehyde, the first product of ethanol metabolization, is a biologically active compound, but the behavioral properties of acetaldehyde in humans are largely undefined. We investigated the acute effects of both alcohol and acetaldehyde
Autor:
Ernest Terwilliger, Catharine A. Winstanley, Imran N. Alibhai, Shari G. Birnbaum, Thomas A. Green, Danielle Graham, Michael T. Bardo, Ami Graham, Eric J. Nestler, Stephen Unterberg, C. Nathaniel Roybal, Caroline E. Bass, David E. H. Theobald, Vincent Vialou
Publikováno v:
Biological Psychiatry. 67:28-35
Background Previous research has shown that rats reared in an enriched condition (EC) are more sensitive to the acute effects of amphetamine than rats reared in an isolated condition (IC); yet, EC rats self-administer less amphetamine than IC rats. T
Autor:
Bastian Hengerer, Amandine Berthet, Daniella Rylander, Stefan Schuster, Evelyne Doudnikoff, Bertrand Bloch, M. Angela Cenci, Incarnation Aubert, Erwan Bezard, D. James Surmeier, Carina Ittrich
Publikováno v:
Biological Psychiatry. 65:518-526
Background: Chronic L-3,4-dihydroxyphenylalanine (L-DOPA) treatment of Parkinson's disease (PD) leads to debilitating involuntary movements, termed L-DOPA-induced dyskinesia. Striatofugal medium spiny neurons (MSN) lose their dendritic spines and cor
Autor:
Marco Bortolato, Sevil Yasar, Zuzana Justinova, Svetlana I. Chefer, Alvin R. King, Jason R. Clapper, Alexey G. Mukhin, Godfrey H. Redhi, Daniele Piomelli, Steven R. Goldberg, Regina A. Mangieri
Publikováno v:
Biological Psychiatry. 64:930-937
Background CB 1 cannabinoid receptors in the brain are known to participate in the regulation of reward-based behaviors. However, the contribution of each of the endocannabinoid transmitters, anandamide and 2-arachidonoylglycerol (2-AG), to these beh
Autor:
Enzo Gori, Tiziana Rubino, Walter Fratta, Paola Mascia, Daniela Parolaro, Mariaelvina Sala, Daniela Braida, Valeria Limonta, Valeria Capurro, Paola Fadda, Alessia Zani
Publikováno v:
Biological Psychiatry. 63:286-292
Background The recreational drug, Salvinorin A, derived from the plant of Salvia divinorum, is a potent and selective κ-opioid receptor agonist. The abuse of selective k-agonists is a novel phenomenon, the mechanism of which is not fully understood.
Autor:
Andrea Tontini, Marco Mor, Andrea Duranti, Janet H. Kim, Regina A. Mangieri, Marco Bortolato, Daniele Piomelli, Oliver Arguello, Giorgio Tarzia, Jin Fu
Publikováno v:
Bortolato, M; Mangieri, RA; Fu, J; Kim, JH; Arguello, O; Duranti, A; et al.(2007). Antidepressant-like Activity of the Fatty Acid Amide Hydrolase Inhibitor URB597 in a Rat Model of Chronic Mild Stress. Biological Psychiatry, 62(10), 1103-1110. doi: 10.1016/j.biopsych.2006.12.001. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8dh7c20g
Background: The endocannabinoid anandamide may be involved in the regulation of emotional reactivity. In particular, it has been shown that pharmacological inhibition of the enzyme fatty acid amide hydrolase (FAAH), which catalyzes the intracellular