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Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1894-1897
The lusitropic effect of quercetin was examined on isolated ventricular myocardial tissue preparations from normal and streptozotocin-induced diabetic mice. The time required for 90% relaxation of the myocardium, which was prolonged in the diabetic m
Autor:
Kouji Tanaka, Kouki Mori, Tomoaki Yoshimura, Yasutaka Shinoda, Machiko Mitsuoka, Tadashi Sugiyama, Tatsuya Hirose, Yuki Kawachi, Ayaka Kuroda, Aya Yoshida, Atsuko Takeda
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:680-684
Daiokanzoto (DKT) and lubiprostone (LPS) are drugs used for constipation, but few studies have compared them. This study examined the effectiveness, adverse events, and medical economic efficiency of DKT and LPS for constipation. Patients who receive
Autor:
Asami Mori, Kenji Sakamoto, Yoshihiro Higashi, Tsutomu Nakahara, Kunio Ishii, Kentaro Higashi
Publikováno v:
Biological and Pharmaceutical Bulletin. 41:1586-1592
Resveratrol, which is a polyphenol found in grapes, peanuts, and other plants, has health benefits for various chronic diseases. The aim of the present study was to examine the effect of resveratrol on cataract formation in diabetic rats. Male Wistar
Publikováno v:
Biological and Pharmaceutical Bulletin. 41:1307-1310
In our research program to find novel agents for alopecia from natural plant resources, we screened Euphorbiaceae plant extracts using an anti-5α-reductase assay. Among the samples tested, the extract of Phyllanthus urinaria showed the most potent a
Autor:
Nahoko Uchiyama, Takuro Maruyama, Hiroshi Odaguchi, Tadatoshi Yamashita, Yoshiaki Amakura, Masashi Hyuga, Sumiko Hyuga, Yukihiro Goda, Jun Takahashi, Naohiro Oshima, Takashi Hakamatsuka, Hiroaki Takemoto, Yoshinori Kobayashi, Toshihiko Hanawa
Publikováno v:
Biological and Pharmaceutical Bulletin. 41:247-253
Ephedrine alkaloids-free Ephedra Herb extract (EFE) has been developed to eliminate the adverse effects caused by ephedrine alkaloid-induced sympathetic hyperactivation. Previously, we reported that EFE possesses analgesic, anti-influenza, and cancer
Autor:
Masami Fujiwara, Kazuhiro Ishida, Takuya Tsutsui, Chiyoko Uchiyama, Hiroyuki Hanihara, Tetsushi Serizawa, Atsushi Naito, Motoyasu Ohdera, Kei Kurita
Publikováno v:
Biological and Pharmaceutical Bulletin. 35:42-47
Neurotrophin (NT)-4 is known to be an inducer of catagen in the hair cycle, but little is known of its role in the pathogenesis of androgenetic alopecia (AGA). We previously studied the gene expression of dermal papilla cells from AGA patients and co
Publikováno v:
Biological and Pharmaceutical Bulletin. 35:65-71
Type I interferons (IFN-α/β) have been widely used in the treatment of many viral and malignant diseases by activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway, but the side effects of protei
Publikováno v:
Biological and Pharmaceutical Bulletin. 35:1-9
We investigated the properties of honokiol, a natural rexinoid, as a regulator of retinoid X receptor (RXR) heterodimers with various partner nuclear receptors (NRs), in comparison with those of the synthetic rexinoid bexarotene. Honokiol alone was h
Publikováno v:
Biological and Pharmaceutical Bulletin. 34:214-218
Candida albicans is the most important human fungal pathogen. Amphotericin (AmB) is a gold standard of antifungal treatment for fungi, but the severe side effect of this drug restricts its clinical application. In this study, the interaction of AmB a
Publikováno v:
Biological and Pharmaceutical Bulletin. 34:1702-1709
Terminalia chebula has been widely used in India as a folk medicine. This study investigated the in vivo anti-hyperglycemia and anti-diabetic complication effects of the EtOAc-soluble portion of ethanolic extract of T. chebula fruit (EETC) containing