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Autor:
Hong Wu, Minoru Yoshiyama, Yoshikatsu Okada, Yasukatsu Izumi, Takehiro Yamaguchi, Yoshio Ijiri, Hideki Imano, Atsuo Nomura, Yudai Yamaguchi, Takashi Nakano, Ryuji Kato, Tetsuya Hayashi, Maki Tamura, Michio Asahi
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:669-677
Pulmonary arterial hypertension (PAH) is a progressive condition that frequently results in right ventricular (RV) remodeling. The objectives of this study are to investigate effects of rivaroxaban on RV remodeling in a rat model of PAH, created with
Autor:
Tatsuya Kitao, Megumi Yamamoto, Masaki Fukui, Yuma Ito, Shohei Furukawa, Hiroaki Shirahase, Ko Morishita
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:659-668
Peroxisome proliferator-activated receptor γ (PPARγ) modulators are expected to exert anti-diabetic effects without PPARγ-related adverse effects, such as fluid retention, weight gain, and bone loss. The present study showed that the novel tetrazo
Autor:
Hiroko Nakamura, Takehiro Kawashiri, Daisuke Kobayashi, Takao Shimazoe, Nobuaki Egashira, Mayako Uchida
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:271-274
The anticancer agents including oxaliplatin, paclitaxel, and bortezomib cause severe peripheral neuropathy. The Kampo medicine Sokeikakketsuto (SOKT) has been widely used to treat several types of pain. In this study, the analgesic effects of SOKT on
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1810-1813
An elevated plasma homocysteine level is an independent risk factor for cardiovascular diseases, neurological disorders, and pregnancy complications. We recently demonstrated partial lactation failure in cystathionine γ-lyase-deficient (Cth-/-) dam
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1556-1561
Renal insufficiency secondary to contrast administration remains a prevalent and debilitating complication of angiographic procedures. Contrast-induced nephropathy (CIN) is a common clinical problem for which there is no effective medical treatment.
Autor:
Mai Hashimoto, Shuhei Imoto, Kazuaki Taguchi, Hiroaki Mitsuya, Keishi Yamasaki, Masaki Otagiri
Publikováno v:
Biol Pharm Bull
A nucleoside analog, 4′-cyano-2′-deoxyguanosine (CdG), which was developed as an inhibitor of the chronic hepatitis B virus (HBV), exhibited a superior antiviral activity against both wild-type and drugs-resistant HBV to marketed nucleoside analo
Autor:
Shuji Masamichi, Atsuki Hosoda, Takumi Tsuji, Yoshio Matsumoto, Takeyuki Kohno, Yuuki Toriyama, Yuya Yoshida
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1331-1337
Cisplatin (CDDP; cis-diamine dichloroplatinum)-induced nephrotoxicity is the main reason for dose limitations, which can reduce the efficacy of cancer treatment. Lower blood pressure and administration of renin angiotensin system (RAS) inhibitors hav
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:1450-1455
Vitiligo is a commom disease of skin. Its pathogenesis is complex, resulting in the incapacity to find a targeted cure. Baicalin, which is isolated from Scutellariae radix, has been known to exhibit a number of pharmacological effects on autoimmune d
Autor:
Masae Yoshikawa, Sang Jun Park, Hiroki Yoshioka, Aya Torii-Goto, Nobuhiko Miura, Rurika Ohishi, Sarah Tominaga, Yui Hirose
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:1562-1568
Chronopharmacology is the study of the varying responses of drugs to changes in biological timing and endogenous periodicities. The dipeptidyl peptidase-4 inhibitor sitagliptin is a globally prescribed anti-hyperglycemic drug. Although dipeptidyl pep
Publikováno v:
Biological and Pharmaceutical Bulletin. 41:1638-1644
Non-alcoholic fatty liver disease (NAFLD) is increasingly prevalent and represents a growing challenge in terms of prevention and treatment. The purpose of this study is to investigate the protective effects of ginsenoside Rg1 (Rg1), an active ingred