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Autor:
Shuji Masamichi, Atsuki Hosoda, Takumi Tsuji, Yoshio Matsumoto, Takeyuki Kohno, Yuuki Toriyama, Yuya Yoshida
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1331-1337
Cisplatin (CDDP; cis-diamine dichloroplatinum)-induced nephrotoxicity is the main reason for dose limitations, which can reduce the efficacy of cancer treatment. Lower blood pressure and administration of renin angiotensin system (RAS) inhibitors hav
Autor:
Hyun-Woo Kim, Jae-Gyun Choi, Yong Sup Shin, Jae-Min Kim, Youngkwon Ko, Jin Bong Park, Hyung Sun Lim, Beyong Hwa Jeon, Jang Hern Lee
Publikováno v:
Biological and Pharmaceutical Bulletin. 36:125-130
Peripheral or central nerve injury often leads to neuropathic pain. Although ketamine and pregabalin are first line options for the treatment of neuropathic pain, their clinical application is limited due to side effects such as sedation, dizziness a
Autor:
Masayuki Arii, Yoshiyuki Adachi, Mitsuhiro Nakajima, Susumu Masuda, Toshiro Yadomae, Toshie Harada, Naohito Ohno
Publikováno v:
Biological and Pharmaceutical Bulletin. 28:2342-2345
Soy isoflavone aglycones (IFAs) have a wide range of biological actions that suggest they may be of use in cancer prevention. On the other hand, a branched beta-glucan from Sparassis crispa (SCG) is a major 6-branched 1,3-beta-D-glucan in an edible/m
Autor:
Xin-Sheng Yao, Hiroshi Kurihara, Yoshinobu Kiso, Sumio Asami, Harukazu Fukami, Hiroshi Shibata, Takaharu Tanaka
Publikováno v:
Biological and Pharmaceutical Bulletin. 26:1393-1397
In normal mice, plasma histamine levels were 29.4+/-10.1 pmol/ml. When 0.1 microg of lipopolysaccharide (LPS) was intravenously injected into Propionibacterium acnes (P. acnes)-primed ICR mice, histamine levels increased remarkably to 61.2+/-15.9 pmo
Autor:
Kenji Manno, Masao Koida, Masaki Ichikawa, Sawako Akashi, Miki Wanaka, Tomokazu Ohtsuji, Hiromichi Nakamuta, Yumiko Machidera
Publikováno v:
Biological and Pharmaceutical Bulletin. 17:1513-1515
Semotiadil fumarate, a novel benzothiazine calcium antagonist, was given alone or in combination with either enalapril or trichlormethiazide to conscious, spontaneously hypertensive, rats daily for 2 weeks. Systolic blood pressure and heart rate were