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Autor:
Hyun-Woo Kim, Jae-Gyun Choi, Yong Sup Shin, Jae-Min Kim, Youngkwon Ko, Jin Bong Park, Hyung Sun Lim, Beyong Hwa Jeon, Jang Hern Lee
Publikováno v:
Biological and Pharmaceutical Bulletin. 36:125-130
Peripheral or central nerve injury often leads to neuropathic pain. Although ketamine and pregabalin are first line options for the treatment of neuropathic pain, their clinical application is limited due to side effects such as sedation, dizziness a
Publikováno v:
Biological and Pharmaceutical Bulletin. 32:51-54
The present study was performed to investigate the effects of histamine H(1)-antagonists on the sleep-awake state in rats placed on a grid suspended over water in comparison with rats placed on sawdust. When rats were placed on the grid suspended ove
Autor:
Yong Soo Kwon, Hyunsu Bae, Moonkyu Kang, Y. E. Kim, Geum-Soog Kim, J.-M. Kim, Kyeong Lee, N. Lee
Publikováno v:
Biological and Pharmaceutical Bulletin. 29:1431-1435
The present study investigates the effects of Yukmijihwang-tang Derivatives (YMJd) on learning and memory through the Morris water maze task and the central cholinergic system of rats with excitotoxic medial septum (MS) lesion. In the water maze test
Autor:
Tomonaga Ichikawa, Kouichi Tanonaka, Kanako Kikuchi, Satoshi Takeo, Keiko Miyake-Takagi, Norio Takagi, Kunio Omino, Tsuyoshi Ando, Hiroshi Kajihara
Publikováno v:
Biological and Pharmaceutical Bulletin. 26:318-322
The effects of nefiracetam on the cerebral adenylyl cyclase (AC) activity of animals with microsphere embolism-induced memory dysfunction were examined. Sustained cerebral ischemia in the right cerebral hemisphere was induced by an injection of micro
Publikováno v:
Biological and Pharmaceutical Bulletin. 20:349-353
Emotional disturbances, such as lack of motivation or depression, are common after stroke. The drugs mainly used to treat these syndromes in Japan are the cerebral metabolic enhancers whose biochemical and pharmacological profiles are similar to thos
Autor:
Ruri Kikura, Yuji Nakahara
Publikováno v:
Biological and Pharmaceutical Bulletin. 20:969-972
Disposition of 3, 4-methylenedioxymethamphetamine (MDMA) in hair roots was studied using rats and the hair root samples were evaluated to prove acute MDMA poisoning. The back hair of male pigmented hairy rats (n=6) was shave and 5 d later the animals
Autor:
S. Nagashima, Mitsuyoshi Nakashima, Seiichi Araki, Toshihiko Uematsu, Masayuki Ishii, Hisakuni Hashimoto, Kazuo Umemura
Publikováno v:
Biological and Pharmaceutical Bulletin. 17:548-550
Electrophysiologic and hemodynamic effects of SD-3212, a new antiarrhythmic drug, were examined and compared with those of flecainide, a class Ic antiarrhythmic drug, in a canine myocardial infarction model. The doses of SD-3212 were 1 mg/kg bolus in