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Publikováno v:
Biological and Pharmaceutical Bulletin. 41:690-696
The purpose of this study was to determine the effects of different concentrations of ligustrazine, an extract from Chinese herb, on ketamine requirement for hypnosis and analgesia in mice. In the hypnotic response study, mice were randomly allocated
Autor:
Akinori Akaike, Yoshinori Kobayashi, Tatsuo Fukuda, Yuka Omameuda, Michiho Ito, Shuji Kaneko, Hiroaki Takemoto
Publikováno v:
Biological and Pharmaceutical Bulletin. 37(6):1050-1055
Dried Nardostachys chinensis roots contain sesquiterpenoids that are widely used as herbal tranquilizers. We previously identified the highly sedative sesquiterpenoid valerena-4, 7(11)-diene (VLD) from this plant. In the present study, we investigate
Publikováno v:
Biological and Pharmaceutical Bulletin. 37:858-864
Diabetic neuropathy is characterized by progressive degeneration of nerve fibers associated with diabetes mellitus. Antidepressants and anticonvulsants are the mainstay of pharmacological treatment, but are often limited in effectiveness against the
Publikováno v:
Biological and Pharmaceutical Bulletin. 37:1816-1819
Pregabalin, (S)-3-isobutyl-γ-aminobutyric acid (GABA), is a widely used adjuvant therapy for patients with neuropathic pain, which is defined as chronic pain caused by lesions or diseases of the somatosensory nervous system. However, dizziness and s
Publikováno v:
Biological and Pharmaceutical Bulletin. 37:1599-1605
Renal ischemia-reperfusion (I/R) injury is a major cause of acute kidney injury via inflammation and cell apoptosis. Volatile anesthetics have been shown to exert organ-protective effects against kidney damage in vivo and in vitro. In the present stu
Publikováno v:
Biological and Pharmaceutical Bulletin. 37:322-326
Oxaliplatin frequently causes peripheral neuropathy. Clinical studies have indicated that pregabalin ameliorates oxaliplatin-induced peripheral neuropathy. However, pregabalin frequently causes dizziness and somnolence. We previously reported that el
Autor:
Hyun-Woo Kim, Jae-Gyun Choi, Yong Sup Shin, Jae-Min Kim, Youngkwon Ko, Jin Bong Park, Hyung Sun Lim, Beyong Hwa Jeon, Jang Hern Lee
Publikováno v:
Biological and Pharmaceutical Bulletin. 36:125-130
Peripheral or central nerve injury often leads to neuropathic pain. Although ketamine and pregabalin are first line options for the treatment of neuropathic pain, their clinical application is limited due to side effects such as sedation, dizziness a
Autor:
Katsunori Iwasaki, Atsunori Shirakawa, Ryoko Okuno, Nobuaki Egashira, Masaki Nagao, Ryozo Oishi, Kenichi Mishima, Michihiro Fujiwara
Publikováno v:
Biological and Pharmaceutical Bulletin. 35:376-379
We examined the role of 5-hydroxytryptamine(2C) (5-HT(2C)) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT(2C) agonist WAY161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT(2C) a
Publikováno v:
Biological and Pharmaceutical Bulletin. 35:2230-2237
Non-steroidal anti-inflammatory drugs (NSAIDs) comprise one of the most frequently used classes of medicines in the world; however, NSAIDs have significant side effects, such as gastroenteropathy, and rheumatoid arthritis patients taking NSAIDs are m
Publikováno v:
Biological and Pharmaceutical Bulletin. 34:1596-1601
The objective of the present study was to evaluate the cardiovascular protective effects of Danshensu, a water-soluble active component of Danshen, in spontaneously hypertensive rats (SHR). SHR (male, 9 weeks old, n=30) were divided into three groups