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Publikováno v:
Biological & Pharmaceutical Bulletin. 41:65-72
In a previous work, we reported the regulatory role of the triterpenoids on 5-hydroxytryptamine (5-HT)3A receptors activity in Xenopus laevis oocytes (Eur. J. Pharmacol., 615, 2009, Lee et al.). In the present report, we studied the modulation of tri
Autor:
Dong-Hoon Shin, Min Chul Gim, Youn-Jung Kim, Gwi Gun Park, Soo Jung Choi, Cho Rong Kim, Chan Kyu Park, Jae Kyeom Kim
Publikováno v:
Biological & Pharmaceutical Bulletin. 40:932-935
We previously reported that the extract of Cinnamomum loureirii (C. loureirii) significantly inhibited acetylcholinesterase (AChE), and identified 2,4-bis(1,1-dimethylethyl)phenol (BP) from C. loureirii as a potential AChE inhibitor. The present stud
Autor:
Shuji Kaneko, Takayuki Nakagawa
Publikováno v:
Biological & Pharmaceutical Bulletin. 40:947-953
Chemotherapy-induced peripheral neuropathy (CIPN), characterized by symptoms of paresthesia, dysesthesia, numbness, and pain, is a common adverse effect of several chemotherapeutic agents, including platinum-based agents, taxanes, and vinca alkaloids
Autor:
Takashi Hirota, Anri Fujishiro, Hideaki Ohashi, Yuka Matsuoka, Ayumi Hiramatsu, Atsushi Miyajima
Publikováno v:
Biological & Pharmaceutical Bulletin. 39:927-934
During the past two decades, it has been reported that treatment with all-trans-retinoic acid (ATRA) induces alveolar regeneration in rodent emphysema models. In the present study, we investigated the regeneration by ATRA at various exposure conditio
Autor:
Yan Chen, Yan Zhou, Bingxue Sun, Yanan Sun, Mengshu Wang, Shubo Liu, Yong Zhang, Wei Kong, Feng Li
Publikováno v:
Biological & Pharmaceutical Bulletin. 39:42-48
The purpose of this study was to investigate the gastrointestinal stability of exenatide to determine the key factor(s) contributing to peptide degradation during the oral delivery process. The effects of pH and various digestive enzymes on the degra
Autor:
Ji-min Park, Hae-Jun Lee, Dae-Sik Jang, Kyung-Tae Lee, Woo-Seok Lee, Heon-Yong Shim, Ji-Sun Shin
Publikováno v:
Biological & Pharmaceutical Bulletin. 39:657-664
We investigated the effect of chikusetsusaponin IVa (CS) and chikusetsusaponin IVa methyl ester (CS-ME) from the roots of Achyranthes japonica NAKAI on lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW26
Publikováno v:
Biological & Pharmaceutical Bulletin. 38:493-496
Antibacterial drug treatment increases the bile acid pool size and hepatic bile acid concentration through the elevation of hepatic bile acid synthesis. However, the involvement of intestinal bile acid absorption in the increased bile acid pool size
Autor:
Noritaka Nakamichi, Takuya Shimizu, Yusuke Masuo, Ai Kijima, Saki Takahashi, Tomoko Sugiura, Takahiro Ishimoto, Yukio Kato
Publikováno v:
Biological & Pharmaceutical Bulletin. 38:774-780
5-Aminosalicylic acid (5-ASA) is an orally administered therapeutic agent for inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease. We hypothesized that the absorption of 5-ASA is mediated by the polyspecific carnitine/organic
Autor:
Kyung-Tae Lee, Byeol Ryu, Ji-Sun Shin, Hwi-Ho Lee, Young-Wuk Cho, Nam-Jung Kim, Yujin Hong, Dae Sik Jang
Publikováno v:
Biological & Pharmaceutical Bulletin. 38:1081-1086
To identify bioactive natural products possessing anti-inflammatory activity, the potential of fulgidic acid from the rhizomes of Cyperus rotundus and the underlying mechanisms involved in its anti-inflammatory activity were evaluated in this study.
Publikováno v:
Biological & Pharmaceutical Bulletin. 30:852-858
The present study investigated the potential cytoprotective properties of a combination of plant extracts (KIOM-79) obtained from Magnolia officinalis, Pueraria lobata, Glycyrrhiza uralensis, and Euphorbia pekinensis, against the oxidative stresses i