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Publikováno v:
Bioengineered
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 2, Pp 12867-12879 (2021)
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 2, Pp 12867-12879 (2021)
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that causes tremors, gait rigidity, and hypokinesia. We determined the effects of long noncoding RNA small nucleolar RNA host gene 12 (lncRNA SNHG12) on the development of PD. Sta
Publikováno v:
Bioengineered
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 8259-8278 (2021)
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 8259-8278 (2021)
Adaptin proteins (APs) play a crucial role in intracellular cell trafficking. The ‘classical’ role of APs is carried out by AP1‒3, which bind to clathrin, cargo, and accessory proteins. Accordingly, AP1–3 are crucial for both vesicle formatio
Publikováno v:
Bioengineered
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 6674-6686 (2021)
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 6674-6686 (2021)
The purpose of this work is to probe into the potential role of long non-coding RNA growth arrest specific transcript 5 (lncGAS5)/ microRNA (miR)-188-5p/SMAD2 axis in MIRI. Through ligating the left anterior descending (LAD) coronary artery, MIRI ani
Publikováno v:
Bioengineered
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 8116-8124 (2021)
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 8116-8124 (2021)
Necrotizing enterocolitis, a devastating gastrointestinal disease with high mortality, poses great threats to global health. Therefore, we conducted this study to explore the role of ANGPT2, as well as the potential mechanism, in necrotizing enteroco
Publikováno v:
Bioengineered
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 3089-3100 (2021)
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 3089-3100 (2021)
It is found that the activation of Sonic Hedgehog (SHH) signaling pathway is related to the degree of inflammation in patients suffering from periodontitis. Cullin3 (CUL3), an important ubiquitin ligase, can control SHH signaling. In this study, we w
Publikováno v:
Bioengineered
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 3148-3158 (2021)
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 3148-3158 (2021)
Dysregulation of long non-coding RNAs (lncRNAs) plays a fundamental role in the development and progression of osteoarthritis (OA), but the potential functions of lncRNAs in OA were not fully clarified. In the present work, we want to clarify the und
Publikováno v:
Bioengineered
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 1663-1675 (2021)
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 1663-1675 (2021)
Long noncoding RNAs (lncRNAs) play vital roles in the progression of hypertrophic scar (HS). We aimed to explore the effect of lncRNA INHBA Antisense RNA1 (INHBA-AS1) in the formation of HS and identify the potential mechanisms. INHBA-AS1 and microRN
Publikováno v:
Bioengineered
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 2095-2105 (2021)
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 2095-2105 (2021)
As gene delivery tools, lentiviral vectors (LV) have broad applications in chimeric antigen receptor therapy (CAR-T). Large-scale production of functional LV is limited by the adherent, serum-dependent nature of HEK293T cells used in the manufacturin
Publikováno v:
Bioengineered
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 2119-2131 (2021)
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 2119-2131 (2021)
The long non-coding RNAs (lncRNAs) participate in modulating numerous important cancer phenotypes via formation of RNA-protein complex. TINCR (terminal differentiation-induced lncRNA) modulates cancer cell behavior in many human malignancies, such as
Autor:
Luxin Zhao, Jie Pan
Publikováno v:
Bioengineered
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 2228-2237 (2021)
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 2228-2237 (2021)
Age-related macular degeneration (AMD) is resulted from choroidal neovascularization (CNV)-mediated cicatrization and vision loss. The sustained retinal hypoxia in retinal pigment epithelium (RPE) cells was reported to contribute to CNV. However, the