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Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1863:2560-2573
Heat shock protein-70kDa (Hsp70) is a member of molecular chaperone family, involved in the proper folding of various proteins. Hsp70 is important for tumor cell survival and is also reported to be involved in enhancing the drug resistance of various
Autor:
Vivian Ruvolo, Numsen Hail, Michael Andreeff, James Rolke, Ahmed AlRawi, R. Eric Davis, Christopher B. Benton, George F. Tidmarsh, Jared K. Burks, Peter P. Ruvolo, Wendy D. Schober
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1863(4):562-571
Galectin 3 (LGALS3) expression is prognostic for poor survival in acute myeloid leukemia (AML) patients. GCS-100 is a novel galectin inhibitor that may prove useful for AML therapy. In this study, we found that GCS-100 induced apoptosis in AML cells.