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Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (10):2220-2232
In Jurkat T cell clone (JT/Neo), G2/M arrest, apoptotic sub-G1 peak, mitochondrial membrane potential (Δψm) loss, and TUNEL-positive DNA fragmentation were induced following exposure to 17α-estradiol (17α-E2), whereas none of these events (except
Autor:
Nuria López-Royuela, Isabel Marzo, Alberto Anel, Patricia Balsas, Patricia Galán-Malo, Javier Naval
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (2):311-322
Glucocorticoids are widely used in anti-myeloma therapy and their action is potentiated by rapamycin, a mTOR inhibitor. However, the molecular mechanisms underlying these effects remain poorly characterized. We show here that dexamethasone (Dex)-indu
Autor:
Claude Cochet, Christophe Hue, Valérie Vilmont, Gilles Chiocchia, Anne-Marie Hesse, Odile Filhol, Yohann Couté, Léa Rémy-Tourneur, Sylvie Mistou
Publikováno v:
Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, 2015, 1853 (11), pp.2885-2896. ⟨10.1016/j.bbamcr.2015.08.001⟩
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2015, 1853 (11), pp.2885-2896. ⟨10.1016/j.bbamcr.2015.08.001⟩
Biochimica et Biophysica Acta-Molecular Cell Research, 2015, 1853 (11), pp.2885-2896. ⟨10.1016/j.bbamcr.2015.08.001⟩
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2015, 1853 (11), pp.2885-2896. ⟨10.1016/j.bbamcr.2015.08.001⟩
The Fas associated death domain protein (FADD) is the key adaptor molecule of the apoptotic signal triggered by death receptors of the TNF-R1 superfamily. Besides its crucial role in the apoptotic machinery, FADD has proved to be important in many bi
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (1-2):79-85
Glucocorticoids are widely used as anti-inflammatory and chemotherapeutic agents. However, prolonged use of glucocorticoids leads to osteoporosis. This study was designed to examine the mechanism of dexamethasone (DEX)-induced apoptosis in murine ost
Publikováno v:
Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2006, 1763 (11), pp.1184-91. ⟨10.1016/j.bbamcr.2006.08.005⟩
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2006, 1763 (11), pp.1184-91. ⟨10.1016/j.bbamcr.2006.08.005⟩
Development of the vertebrate embryonic nervous system is characterized by a cascade of signalling events. In Xenopus, the initial step in this cascade results from signals emanating from the dorsal mesoderm that divert the fate of the ectoderm from