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Autor:
Qihan Wang, Guo Wenhui, Long Jiao, Wentao Shao, Qifan Lu, Hai Hu, Chaobo Chen, Qian Liu, Zhenkun Weng, Aihua Gu, Zhaoyan Jiang, Yaoyao Chen, Haidong Sun
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:2576-2585
Trimethylamine-N-oxide (TMAO) is a metabolite derived from trimethylamine (TMA), which is first produced by gut microbiota and then oxidized by flavin-containing monooxygenase 3 (FMO3) in the liver. TMAO may contribute to the development of diseases
Autor:
Jie-Ning Zhu, Xian-Hong Fang, Hui Li, Rong Pan, Jian-Fang Luo, Jing Yang, Jin-Dong Xu, Zhen Xiao, Jingnan Liang, Xiao Zou, Ming Zhang, Sheng Wang, Shujing Yuan, Ni Zeng, Zhi-Xin Shan, Yong-Heng Fu
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:2441-2450
Although macrophage migration inhibitory factor (MIF) is known to have antioxidant property, the role of MIF in cardiac fibrosis has not been well understood. We found that MIF was markedly increased in angiotension II (Ang-II)-infused mouse myocardi
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:2303-2316
Reactive oxygen species (ROS) are capable of inducing cell death or apoptosis. Recently, we demonstrated that lipid-ROS can mediate ferroptosis and activation of human platelets. Ferroptosis is an intracellular iron-mediated cell death, distinct from
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:2285-2292
d -Ribose is active in glycation and rapidly produces advanced glycation end products, leading to cell death and to cognitive impairment in mice. Glycated serum protein (GSP) is a relatively short-term biomarker for glycemic control in diabetes melli
Autor:
Yuyao Wang, Yu Chen, Jun Cai, Weili Zhang, Bin Lv, Shuyuan Zhang, Shujun Yang, Zhihui Hou, Jian Li, Rutai Hui, Congrui Feng
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:1772-1781
Macrophages exhibit heterogeneity and plasticity and imbalance between pro-inflammatory and anti-inflammatory macrophages plays a critical role in atherosclerosis progression. Telomerase reverse transcriptase (TERT) in macrophages can be activated by
Dietary cholesterol is essential to mast cell activation and associated obesity and diabetes in mice
Autor:
Xiang Yan, Qin Huang, Jie Li, Zhiyong Deng, Peter Libby, Jari Metso, Guo-Ping Shi, Xin Wang, Matti Jauhiainen, Jian Liu, Xian Zhang
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:1690-1700
Mast cell (MC) deficiency in KitW-sh/W-sh mice and inhibition with disodium chromoglycate (DSCG) or ketotifen reduced obesity and diabetes in mice on a high-cholesterol (1.25%) Western diet. Yet, Kit-independent MC-deficient mice and mice treated wit
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:570-576
Sphingosine kinases phosphorylate sphingosine to sphingosine 1-phosphate (S1P), which functions as a signaling molecule. We have previously shown that sphingosine kinase 2 (Sphk2) is important for insulin secretion. To obtain a better understanding o
Autor:
Mariah Lee, Raghavan Raju, Kumar Subramani, Marie Warren, Xiaogang Chu, Sumin Lu, Nagendra Singh
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:688-695
Inflammation and cellular energetics play critical roles in organ dysfunction following hemorrhagic shock. Recent studies suggest a putative role for sirtuin 1 (SIRT1) in potentiating mitochondrial function and improving organ function following hemo
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:678-687
Hexokinase domain containing 1, a recently discovered putative fifth hexokinase, is hypothesized to play key roles in glucose metabolism. Specifically, during pregnancy in a recent genome wide association study (GWAS), a strong correlation between HK
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:445-453
Published research suggests that activation of transient receptor potential vanilloid subfamily 1 (TRPV1) enhances the expression and deacetylation of peroxisome proliferator-activated receptor gamma (PPARγ) to cause browning of white adipose tissue