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Autor:
Luis A. Cea, Rosalba Escamilla, Elisa Balboa, Juan C. Sáez, María C. Brañes, Carlos Puebla, Tomás Regueira, Aníbal A. Vargas
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:2765-2773
Endotoxemia caused by bacterial lipopolysaccharides (LPSs) leads to severe skeletal muscular deterioration, starting with higher membrane permeability and decline in resting membrane potential (RMP). However, the molecular mechanism of such changes r
Autor:
Wen-Su Lee, Michael Glogauer, Nuno M. Coelho, Christopher A. McCulloch, J. Tanic, Yongqiang Wang
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:2716-2725
Adseverin (Ads) is a Ca2+-dependent actin-capping and severing protein that is highly expressed in gastric, prostate and bladder cancer cells. Currently it is unknown whether Ads contributes to the subcortical actin remodeling associated with the for
Autor:
María Esteban-Lopez, Cristina Fábregas, Biel Taltavull, José Rodríguez-Alvarez, Rut Fadó, Alfredo J. Miñano-Molina, Núria Casals, Montse Solé, Mercedes Unzeta
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:2189-2202
Dysfunctions of the vascular system directly contribute to the onset and progression of Alzheimer's disease (AD). The blood-brain barrier (BBB) shows signs of malfunction at early stages of the disease. When Abeta peptide (Aβ) is deposited on brain
Autor:
Ji-Young Lee, Minkyung Bae, Yoojin Lee, Siqi Hu, Mi-Bo Kim, Tho X. Pham, Hyunju Kang, Young-Ki Park
Publikováno v:
Biochim Biophys Acta Mol Basis Dis
Objective Liver fibrosis is part of the non-alcoholic fatty liver disease (NAFLD) spectrum, which currently has no approved pharmacological treatment. In this study, we investigated whether supplementation of nicotinamide riboside (NR), a nicotinamid
Autor:
Patrick M. Catalano, Marc Baumann, Marcus Borges, Janet Pullockaran, Stacy Zamudio, Nicholas P. Illsley
Publikováno v:
Biochim Biophys Acta Mol Basis Dis
We have previously described regulation of syncytial GLUT1 glucose transporters by IGF-I. Despite this, it is not clear what signal regulates transplacental glucose transport. In this report we asked whether changes in GLUT1 expression and glucose tr
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:2048-2059
Uncover the initial cause(s) underlying Alzheimer's disease (AD) pathology is imperative for the development of new therapeutic interventions to counteract AD-related symptomatology and neuropathology in a timely manner. The early stages of AD are ch
Publikováno v:
Junqueira, S C, Centeno, E G Z, Wilkinson, K & Cimarosti, H I 2019, ' Post-translational modifications of Parkinson's disease-related proteins : Phosphorylation, SUMOylation and Ubiquitination ', Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, vol. 1865, no. 8, pp. 2001-2007 . https://doi.org/10.1016/j.bbadis.2018.10.025
Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the nigrostriatal pathway. The etiology of PD remains unclear and most cases are sporadic, however genetic mutations in more than 20 proteins ha
Autor:
Jingmin Zhou, Xiaolei Sun, Fan Fan, Peng Xiuhua, Xiangwei Liu, Meng Yuan, Yunzeng Zou, Junbo Ge, Xiaohui Zhou, Zhen Dong, Zeng Wang, Hong Zhu, Quan Cao, Jingjing Zhao, Cong Wang, Yingmei Zhang
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:1782-1792
Previous evidence has indicated a beneficial role for aldehyde dehydrogenase 2 (ALDH2) in suppressing atherosclerotic plaque progression and instability. However, the underlying mechanism remains somewhat elusive. This study was designed to examine t
Dietary cholesterol is essential to mast cell activation and associated obesity and diabetes in mice
Autor:
Xiang Yan, Qin Huang, Jie Li, Zhiyong Deng, Peter Libby, Jari Metso, Guo-Ping Shi, Xin Wang, Matti Jauhiainen, Jian Liu, Xian Zhang
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:1690-1700
Mast cell (MC) deficiency in KitW-sh/W-sh mice and inhibition with disodium chromoglycate (DSCG) or ketotifen reduced obesity and diabetes in mice on a high-cholesterol (1.25%) Western diet. Yet, Kit-independent MC-deficient mice and mice treated wit
Autor:
Maria-Isabel Yuseff, Alejandra R. Alvarez, Cristian Valls, Silvana Zanlungo, Catalina De la Fuente, Juan Esteban Oyarzún, Jonathan Lagos, Mary Carmen Vázquez
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:1076-1087
Lysosomes are dynamic organelles, which can fuse with a variety of targets and undergo constant regeneration. They can move along microtubules in a retrograde and anterograde fashion by using motor proteins, kinesin and dynein, being main players in